Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 1 [194-712]

Ligand

BDBM348068

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Assay

IC50

<100±n/a nM

Citation

Jorand-Lebrun, C; Jones, R; Won, AC; Nguyen, N; Johnson, TL; Deselm, LC; Panda, K Heteroaryl compounds as IRAK inhibitors and uses thereof US Patent US9790221 Publication Date 10/17/2017

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 1 [194-712]

Name:

Interleukin-1 receptor-associated kinase 1 [194-712]

Synonyms:

IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

55943.99

Organism:

Homo sapiens (Human)

Description:

aa 194-712

Residue:

519

Sequence:

RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK
QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP
QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS
QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKY
LKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGL
GQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGR
AHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPA
PLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKL
ALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS

BDBM348068

n/a

Name

BDBM348068

Synonyms:

US9790221, Compound 276

Type

Small organic molecule

Emp. Form.

C27H32N8O2S

Mol. Mass.

532.66

SMILES

Cn1cc(cn1)-c1cccc(c1)-c1ncc(-c2cnn(C)c2)c(N[C@H]2CC[C@@H](CC2)NS(=O)(=O)C2CC2)n1 |r,wU:27.33,wD:24.26,(1.09,5.84,;-.4,6.23,;-1.3,4.99,;-2.77,5.46,;-2.77,7,;-1.3,7.48,;-4.1,4.69,;-5.44,5.46,;-6.77,4.69,;-6.77,3.15,;-5.44,2.38,;-4.1,3.15,;-5.44,.84,;-6.77,.07,;-6.77,-1.47,;-5.44,-2.24,;-5.44,-3.78,;-6.68,-4.68,;-6.21,-6.15,;-4.67,-6.15,;-3.9,-7.48,;-4.19,-4.68,;-4.1,-1.47,;-2.77,-2.24,;-1.44,-1.47,;-.11,-2.24,;1.23,-1.47,;1.23,.07,;-.11,.84,;-1.44,.07,;2.56,.84,;3.9,.07,;3.13,-1.26,;4.67,-1.26,;5.23,.84,;6.77,.84,;6,2.18,;-4.1,.07,)|

Structure