Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAmine oxidase [flavin-containing] A
LigandBDBM15585
Substrate/CompetitorBDBM10990
Meas. Tech.MAO Activity Assay
pH7.4±n/a
Temperature311.15±n/a K
Ki 420±n/a nM
Citation La Regina, G; Silvestri, R; Artico, M; Lavecchia, A; Novellino, E; Befani, O; Turini, P; Agostinelli, E New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem50:922-31 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Amine oxidase [flavin-containing] A
Name:Amine oxidase [flavin-containing] A
Synonyms:AOFA_BOVIN | Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A | Monoamine oxidase type A
Type:PROTEIN
Mol. Mass.:59764.63
Organism:Bos taurus
Description:ChEMBL_1501477
Residue:527
Sequence:
MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHV
DYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKL
RSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADR
LAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAED
VPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM15585
BDBM10990
NameBDBM15585
Synonyms:N-(2-phenylethyl)-1H-pyrrole-2-carboxamide | N-2-Phenylethyl-1H-pyrrole-2-carboxamide | pyrrole inhibitor 11
TypeSmall organic molecule
Emp. Form.C13H14N2O
Mol. Mass.214.2631
SMILESO=C(NCCc1ccccc1)c1ccc[nH]1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: