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TargetAmine oxidase [flavin-containing] A
LigandBDBM15611
Substrate/CompetitorBDBM10990
Meas. Tech.MAO Activity Assay
Ki 5.4±n/a nM
Citation La Regina, G; Silvestri, R; Artico, M; Lavecchia, A; Novellino, E; Befani, O; Turini, P; Agostinelli, E New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem50:922-31 (2007) [PubMed]  Article
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Amine oxidase [flavin-containing] A
Name:Amine oxidase [flavin-containing] A
Synonyms:AOFA_BOVIN | Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A | Monoamine oxidase type A
Type:PROTEIN
Mol. Mass.:59764.63
Organism:Bos taurus
Description:ChEMBL_1501477
Residue:527
Sequence:
MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHV
DYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKL
RSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADR
LAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAED
VPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
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BDBM15611
BDBM10990
NameBDBM15611
Synonyms:N-Methyl,N-(propargyl),N-(pyrrol-2-ylmethyl)amine | methyl(prop-2-yn-1-yl)(1H-pyrrol-2-ylmethyl)amine | pyrrole inhibitor 4
TypeSmall organic molecule
Emp. Form.C9H12N2
Mol. Mass.148.205
SMILESCN(CC#C)Cc1ccc[nH]1
Structure
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