| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 8 |
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| Ligand | BDBM15871 |
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| Substrate/Competitor | biotinylated GST-ATF2 |
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| Meas. Tech. | ATF-2 Phosphorylation Assay |
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| pH | 7.2±n/a |
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| Temperature | 293.15±n/a K |
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| IC50 | >10000±n/a nM |
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| Citation |  Liu, M; Xin, Z; Clampit, JE; Wang, S; Gum, RJ; Haasch, DL; Trevillyan, JM; Abad-Zapatero, C; Fry, EH; Sham, HL; Liu, G Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors. Bioorg Med Chem Lett16:2590-4 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Mitogen-activated protein kinase 8 |
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| Name: | Mitogen-activated protein kinase 8 |
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| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48297.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 427 |
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| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
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| BDBM15871 |
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| biotinylated GST-ATF2 |
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| Name: | biotinylated GST-ATF2 |
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| Synonyms: | ATF-2-GST | ATF2 | Activating transcription factor 2 | Activating transcription factor 2-GST fusion | GST-ATF2 | biotinylated ATF2 substrate | biotinylated activating transcription factor 2 |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 12237.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 109 |
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| Sequence: | MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKN
CEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPS
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