Reaction Details |
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Target | Aldo-keto reductase family 1 member A1 |
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Ligand | BDBM16480 |
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Substrate/Competitor | BDBM16241 |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | 10000±n/a nM |
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Citation | Van Zandt, MC; Jones, ML; Gunn, DE; Geraci, LS; Jones, JH; Sawicki, DR; Sredy, J; Jacot, JL; Dicioccio, AT; Petrova, T; Mitschler, A; Podjarny, AD Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. J Med Chem48:3141-52 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Aldo-keto reductase family 1 member A1 |
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Name: | Aldo-keto reductase family 1 member A1 |
Synonyms: | AK1A1_HUMAN | AKR1A1 | ALDR1 | ALR | Alcohol dehydrogenase [NADP+] | Aldehyde Reductase (ALR1) | Aldehyde reductase | Aldo-keto reductase family 1 member A1 |
Type: | Enzyme |
Mol. Mass.: | 36574.11 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 325 |
Sequence: | MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
PMLTVDGKRVPRDAGHPLYPFNDPY
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BDBM16480 |
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BDBM16241 |
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Name | BDBM16480 |
Synonyms: | 2-{5-phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acid | Indoleacetic Acid Inhibitor 37 |
Type | Small organic molecule |
Emp. Form. | C24H15F3N2O2S |
Mol. Mass. | 452.448 |
SMILES | OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2cc(ccc12)-c1ccccc1 |
Structure |
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