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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Ligand | BDBM354669 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HTRF assay | ||
| IC50 | 5.5±n/a nM | ||
| Citation |  Armani, E; Amari, G; Blackaby, W; Van De Poel, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent US9809582 Publication Date 11/7/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
| Type: | Protein | ||
| Mol. Mass.: | 83318.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07343 | ||
| Residue: | 736 | ||
| Sequence: |
| ||
| BDBM354669 | |||
| n/a | |||
| Name | BDBM354669 | ||
| Synonyms: | US9809582, Example 12 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C43H47Cl2N3O7 | ||
| Mol. Mass. | 788.755 | ||
| SMILES | COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CCN2CCC(CC2)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)cc1 |r,wU:10.22,wD:39.41,(-6.67,-9.24,;-5.33,-10.01,;-4,-9.24,;-2.67,-10.01,;-1.33,-9.24,;-1.33,-7.7,;-2.67,-6.93,;-4,-7.7,;-5.33,-6.93,;-6.67,-7.7,;,-6.93,;1.33,-7.7,;2.67,-6.93,;4,-7.7,;4,-9.24,;5.33,-6.93,;5.33,-5.39,;6.67,-4.62,;4,-4.62,;2.67,-5.39,;1.33,-4.62,;,-5.39,;-1.33,-4.62,;-2.67,-5.39,;-1.33,-3.08,;,-2.31,;,-.77,;-1.33,,;-1.33,1.54,;,2.31,;,3.85,;1.33,4.62,;1.33,6.16,;,6.93,;-1.33,6.16,;-1.33,4.62,;1.33,7.7,;1.33,9.24,;2.67,6.93,;4,7.7,;5.33,6.93,;6.67,7.7,;6.67,9.24,;5.33,10.01,;4,9.24,;5.54,9.24,;5.13,7.7,;-1.33,7.7,;-1.33,9.24,;-2.67,10.01,;-4,9.24,;-4,7.7,;-2.67,6.93,;-2.67,-.77,;-2.67,-2.31,)| | ||
| Structure | 
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