Ki Summary

Reaction Details

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Target

Probable glutamate--tRNA ligase, mitochondrial

Ligand

BDBM18122

Substrate/Competitor

BDBM17657

Meas. Tech.

Determination of the Inhibition Type and Constant (Ki)

8±n/a

Temperature

303.15±n/a K

70±n/a nM

Citation

Bernier, S; Dubois, DY; Habegger-Polomat, C; Gagnon, LP; Lapointe, J; Chênevert, R Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase. J Enzyme Inhib Med Chem20:61-7 (2005) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Probable glutamate--tRNA ligase, mitochondrial

Name:

Probable glutamate--tRNA ligase, mitochondrial

Synonyms:

Ears2 | Glutamate--tRNA ligase | Kiaa1970 | SYEM_MOUSE | tRNA synthetase (GluRS)

Type:

Enzyme

Mol. Mass.:

58341.27

Organism:

Mus musculus (mouse)

Description:

Partially purified fraction from mouse liver containing aaRS.

Residue:

523

Sequence:

MAAPLKRLLLAEPHVVALGHRVGRREASLGPDPGAPVRVRFAPSPTGFLHLGGLRTALYN
YIFAKKHQGSFILRLEDTDQSRLVPGAAESIEDMLEWAGIPPDESPRRGGPAGPYCQSQR
LALYAQATEALLRSGAAYPCFCLPQRLELLKKEALRSRQTPRYDNRCRNLSQAQVAQKLA
VDPKPAIRFRLEEAVPAFQDLVYGWTQHEVASVEGDPVILKSDGFPTYHLACVVDDHHMS
ISHVLRGSEWLVSTSKHLLLYQALGWQPPRFAHLPLLLNRDGSKLSKRQGDIFLEHFAAT
GFLPEALLDIITNCGSGFAENQMGRTLPELITQFDLTRITCHSALLDLEKLPEFNRLHLR
RLVSSETQRPQLVEKLQGLVKEAFGSELQNKDVLDPAYMERILLLRQGHISRLQDLVSPV
YSYLWTRPAVHRSELGASSENVDVIAKRLLGLLERPGLSLTQDVLNRELKKLSEGLEGAK
HSSVMKLLRMALSGQLQGPPVAEMMVSLGPKEVRERIQKVLSS

BDBM18122

BDBM17657

Name

BDBM18122

Synonyms:

(4S)-4-amino-5-[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}sulfonyl)amino]-5-oxopentanoic acid | 5-O-[N-(L-Glutamyl)-sulfamoyl]adenosine 5 | Glu-AMS

Type

Small organic molecule

Emp. Form.

C15H21N7O9S

Mol. Mass.

475.434

SMILES

N[C@@H](CCC(O)=O)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|

Structure