| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM18225 |
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| Substrate/Competitor | BDBM18044 |
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| Meas. Tech. | In Vitro Inhibition Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 600±110 nM |
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| Citation |  Joska, TM; Anderson, AC Structure-activity relationships of Bacillus cereus and Bacillus anthracis dihydrofolate reductase: toward the identification of new potent drug leads. Antimicrob Agents Chemother50:3435-43 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 19144.66 |
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| Organism: | Bacillus cereus (ATCC 14579) |
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| Description: | Q81E04 |
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| Residue: | 162 |
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| Sequence: | MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRN
IIVTRNEGYHVEGCEVVHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHA
FEGDTFFPEIDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKQQ
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| BDBM18225 |
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| BDBM18044 |
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| Name | BDBM18225 |
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| Synonyms: | 2,4-diamino-5-deazapteridine, 4 | 4-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl}methyl)-4-methoxyphenoxy]butanoic acid | Piritrexim analogue, 6 | pyrido[2,3-d]pyrimidine analogue |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N5O4 |
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| Mol. Mass. | 397.4277 |
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| SMILES | COc1ccc(OCCCC(O)=O)cc1Cc1cnc2nc(N)nc(N)c2c1C |
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| Structure | 
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