Reaction Details |
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Target | Nuclear receptor ROR-gamma |
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Ligand | BDBM359502 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biological Assay |
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IC50 | 2.40±n/a nM |
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Citation | Lapointe, BT; Fuller, PH; Gunaydin, H; Liu, K; Sciammetta, N; Trotter, BW; Zhang, H; Barr, KJ; Maclean, JK; Molinari, DF; Simov, V Substituted pyrazole compounds as RORgammaT inhibitors and uses thereof US Patent US10221142 Publication Date 3/5/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor ROR-gamma |
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Name: | Nuclear receptor ROR-gamma |
Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 58218.40 |
Organism: | Homo sapiens (Human) |
Description: | P51449 |
Residue: | 518 |
Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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BDBM359502 |
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n/a |
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Name | BDBM359502 |
Synonyms: | 4-(6-(azetidine-1-carbonyl)-1- (2-chloro-6- cyclopropylbenzoyl)-4,5,6,7- tetrahydro-1H-indazol-3-yl)-3- fluorobenzoic acid | US10221142, Example 6B |
Type | Small organic molecule |
Emp. Form. | C28H25ClFN3O4 |
Mol. Mass. | 521.967 |
SMILES | OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3CC(CCc23)C(=O)N2CCC2)c(F)c1 |
Structure |
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