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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Coagulation factor X | ||
| Ligand | BDBM19025 | ||
| Substrate/Competitor | BDBM12500 | ||
| Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants. | ||
| pH | 7±n/a | ||
| Temperature | 295.15±n/a K | ||
| Ki | 5.7±n/a nM | ||
| Citation |  Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues. Bioorg Med Chem Lett17:1432-7 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Coagulation factor X | |||
| Name: | Coagulation factor X | ||
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 54726.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM19025 | |||
| BDBM12500 | |||
| Name | BDBM19025 | ||
| Synonyms: | 1-[3-(aminomethyl)phenyl]-N-[4-(2-methanesulfonylphenyl)cyclohexyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide | DPC 423 derivative, 5 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H27F3N4O3S | ||
| Mol. Mass. | 520.567 | ||
| SMILES | CS(=O)(=O)c1ccccc1[C@H]1CC[C@@H](CC1)NC(=O)c1cc(nn1-c1cccc(CN)c1)C(F)(F)F |r,wU:13.17,wD:10.10,(6.57,7.3,;6.57,5.76,;5.03,5.76,;8.11,5.76,;6.57,4.22,;7.9,3.45,;7.9,1.91,;6.57,1.14,;5.24,1.91,;5.24,3.45,;3.9,4.22,;3.9,5.76,;2.57,6.53,;1.24,5.76,;1.24,4.22,;2.57,3.45,;-.23,6.23,;-1.37,5.2,;-1.05,3.69,;-2.84,5.68,;-3.31,7.14,;-4.85,7.14,;-5.33,5.68,;-4.08,4.77,;-4.08,3.23,;-2.75,2.46,;-2.75,.92,;-4.08,.15,;-5.42,.92,;-6.75,.15,;-8.08,.92,;-5.42,2.46,;-5.76,8.39,;-6.53,9.72,;-4.47,9.23,;-7.05,7.55,)| | ||
| Structure | 
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