| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin K |
|---|
| Ligand | BDBM19648 |
|---|
| Substrate/Competitor | BDBM19583 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| Ki | >30000±n/a nM |
|---|
| Citation |  Chatterjee, AK; Liu, H; Tully, DC; Guo, J; Epple, R; Russo, R; Williams, J; Roberts, M; Tuntland, T; Chang, J; Gordon, P; Hollenbeck, T; Tumanut, C; Li, J; Harris, JL Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorg Med Chem Lett17:2899-903 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Cathepsin K |
|---|
| Name: | Cathepsin K |
|---|
| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36975.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43235 |
|---|
| Residue: | 329 |
|---|
| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
|
|
|
|---|
| BDBM19648 |
|---|
| BDBM19583 |
|---|
| Name | BDBM19648 |
|---|
| Synonyms: | (2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo-N-[(1S)-1-phenyl-2-{[4-(trifluoromethoxy)phenyl]amino}ethyl]butanamide | succinamide peptidomimetic, 14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H38F3N3O4 |
|---|
| Mol. Mass. | 561.6356 |
|---|
| SMILES | FC(F)(F)Oc1ccc(NC[C@@H](NC(=O)[C@H](CC2CCCCC2)CC(=O)N2CCOCC2)c2ccccc2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
