Reaction Details |
| Report a problem with these data |
Target | Procathepsin L |
---|
Ligand | BDBM19667 |
---|
Substrate/Competitor | BDBM19584 |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
Ki | >100000±n/a nM |
---|
Citation | Chatterjee, AK; Liu, H; Tully, DC; Guo, J; Epple, R; Russo, R; Williams, J; Roberts, M; Tuntland, T; Chang, J; Gordon, P; Hollenbeck, T; Tumanut, C; Li, J; Harris, JL Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorg Med Chem Lett17:2899-903 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Procathepsin L |
---|
Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
|
|
|
BDBM19667 |
---|
BDBM19584 |
---|
Name | BDBM19667 |
Synonyms: | (2S)-2-(4-chlorophenyl)-N-[(2S)-3-methyl-1-{[4-(trifluoromethoxy)phenyl]amino}butan-2-yl]-4-(morpholin-4-yl)-4-oxobutanamide | succinamide peptidomimetic, 33 |
Type | Small organic molecule |
Emp. Form. | C26H31ClF3N3O4 |
Mol. Mass. | 541.99 |
SMILES | CC(C)[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@@H](CC(=O)N1CCOCC1)c1ccc(Cl)cc1 |r| |
Structure |
|