| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ALK tyrosine kinase receptor |
|---|
| Ligand | BDBM243373 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibitory Activity Against Anaplastic Lymphoma Kinase (ALK) |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 1.000±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Yun, CS; Kim, HR; Cho, SY; Jung, HJ; Lee, K; Chae, CH; Lee, CO; Park, CH; Kim, P; Hwang, JY; Ha, JD; Ahn, SJ Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient US Patent US10053458 Publication Date 8/21/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| ALK tyrosine kinase receptor |
|---|
| Name: | ALK tyrosine kinase receptor |
|---|
| Synonyms: | ALK | ALK tyrosine kinase receptor (ALK) | ALK_HUMAN | Anaplastic lymphoma kinase | CD_antigen: CD246 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 176453.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UM73 |
|---|
| Residue: | 1620 |
|---|
| Sequence: | MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVV
PSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEA
RTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQ
GEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDY
FTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQ
MDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGR
YIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFF
ALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYC
NFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFP
APIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPL
LDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNP
NKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPL
KGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGE
DACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLII
AAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGA
TGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFIS
PLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVS
CIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKL
SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPN
DPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMA
GGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP
GPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW
EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIIL
ERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAA
PPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPT
SLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPS
SLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
|
|
|
|---|
| BDBM243373 |
|---|
| n/a |
|---|
| Name | BDBM243373 |
|---|
| Synonyms: | 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-methoxy-2-hydroxyethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)pyrimidine-2,4-diamine | US10053458, 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H30ClN5O4S |
|---|
| Mol. Mass. | 532.055 |
|---|
| SMILES | COc1cc2CN(CCO)CCc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
