Reaction Details |
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Target | Signal transducer and activator of transcription 1-alpha/beta/3 |
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Ligand | BDBM20283 |
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Substrate/Competitor | c-fos sis inducible element (hSIE) |
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Meas. Tech. | Electrophoretic Mobility Shift Assay (EMSA) |
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pH | 7.8±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 160000±43000 nM |
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Citation | Siddiquee, K; Zhang, S; Guida, WC; Blaskovich, MA; Greedy, B; Lawrence, HR; Yip, ML; Jove, R; McLaughlin, MM; Lawrence, NJ; Sebti, SM; Turkson, J Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A104:7391-6 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Signal transducer and activator of transcription 1-alpha/beta/3 |
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Name: | Signal transducer and activator of transcription 1-alpha/beta/3 |
Synonyms: | STAT1:STAT3 Dimer | Transcription Factor STAT1:STAT3 Dimer |
Type: | Dimer |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Signal transducer and activator of transcription 3 |
Synonyms: | Acute-phase response factor | Aprf | STAT3 alpha | STAT3_MOUSE | Signal transducer and activator of transcription 3 | Stat3 | Transcription Factor STAT3 |
Type: | Cytosolic Transcription Factor |
Mol. Mass.: | 88050.28 |
Organism: | Mus musculus (mouse) |
Description: | Bacterially expressed protein was used in the FP assay. |
Residue: | 770 |
Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
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Component 2 |
Name: | Signal transducer and activator of transcription 1-alpha/beta |
Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
Type: | Cytosolic Transcription Factor |
Mol. Mass.: | 87327.69 |
Organism: | Homo sapiens (Human) |
Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
Residue: | 750 |
Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
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BDBM20283 |
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c-fos sis inducible element (hSIE) |
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Name: | c-fos sis inducible element (hSIE) |
Synonyms: | 32P-labeled c-fos sis inducible element (hSIE) |
Type: | Oligonucleotide |
Mol. Mass.: | 2192.56 |
Organism: | n/a |
Description: | hSIE derived from the c-fos gene promoter. |
Residue: | 24 |
Sequence: | |