Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM21364 |
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Substrate/Competitor | BDBM21342 |
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Meas. Tech. | Radioligand Labeled Binding Assay |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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Ki | 25±n/a nM |
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Citation | Cole, DC; Stock, JR; Lennox, WJ; Bernotas, RC; Ellingboe, JW; Boikess, S; Coupet, J; Smith, DL; Leung, L; Zhang, GM; Feng, X; Kelly, MF; Galante, R; Huang, P; Dawson, LA; Marquis, K; Rosenzweig-Lipson, S; Beyer, CE; Schechter, LE Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. J Med Chem50:5535-8 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM21364 |
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BDBM21342 |
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Name | BDBM21364 |
Synonyms: | 3-[(E)-[(5-bromo-1H-indol-3-yl)methylidene]amino]guanidine | 5-bromoindole aminoguanidine, 6 |
Type | Small organic molecule |
Emp. Form. | C10H10BrN5 |
Mol. Mass. | 280.124 |
SMILES | NC(N)=NN=Cc1c[nH]c2ccc(Br)cc12 |w:5.5,(2.73,6.82,;1.96,8.16,;2.73,9.49,;.42,8.16,;-.35,6.82,;-1.86,6.5,;-2.34,5.04,;-1.43,3.79,;-2.34,2.55,;-3.8,3.02,;-5.13,2.25,;-6.47,3.02,;-6.47,4.56,;-7.8,5.33,;-5.13,5.33,;-3.8,4.56,)| |
Structure |
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