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TargetG protein-coupled receptor 44
LigandBDBM21610
Substrate/CompetitorBDBM21544
Meas. Tech.Radioligand Binding Assay and [35S] GTP-gamma-S Binding Assay
Ki 5±n/a nM
Citation Crosignani SPage PMissotten MColovray VCleva CArrighi JFAtherall JMacritchie JMartin THumbert YGaudet MPupowicz DMaio MPittet PAGolzio LGiachetti CRocha CBernardinelli GFilinchuk YScheer ASchwarz MKChollet A Discovery of a New Class of Potent, Selective, and Orally Bioavailable CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases. J Med Chem 51:2227-2243 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
G protein-coupled receptor 44
Name:G protein-coupled receptor 44
Synonyms:CD294 antigen
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42975.89
Organism:Mus musculus (mouse)
Description:Human embryonic kidney (HEK) 293(EBNA) cells were transfected with mouse CRTH2.
Residue:382
Sequence:
MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRM
RQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFL
LSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIM
CYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRT
GRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNP
LLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIP
QLRPTRLIGWMRRGSAEVPQRV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM21610
BDBM21544
NameBDBM21610
Synonyms:2-[(3R)-5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2,2',5'-trione]acetic acid | Spiro-indolinone analogue, (R)-71
TypeSmall organic molecule
Emp. Form.C20H13Cl2FN2O5
Mol. Mass.451.232
SMILESOC(=O)CN1C(=O)[C@@]2(CC(=O)N(Cc3cc(Cl)ccc3F)C2=O)c2cc(Cl)ccc12 |r|
Structure
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