| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate Transporter 1 |
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| Ligand | BDBM22015 |
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| Substrate/Competitor | BDBM21986 |
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| Meas. Tech. | Radioligand Filter Binding Assay |
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| pH | 7.8±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 4.9±n/a nM |
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| Citation |  Guile SD; Bantick JR; Cheshire DR; Cooper ME; Davis AM; Donald DK; Evans R; Eyssade C; Ferguson DD; Hill S; Hutchinson R; Ingall AH; Kingston LP; Martin I; Martin BP; Mohammed RT; Murray C; Perry MW; Reynolds RH; Thorne PV; Wilkinson DJ; Withnall J Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds. Bioorg Med Chem Lett 16:2260-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Monocarboxylate Transporter 1 |
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| Name: | Monocarboxylate transporter 1 |
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| Synonyms: | MCT 1 | Solute carrier family 16 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53956.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1451367 |
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| Residue: | 500 |
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| Sequence: | MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
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| BDBM22015 |
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| BDBM21986 |
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| Name | BDBM22015 |
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| Synonyms: | 5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-methyl-1-(2-methylpropyl)-6-{[2-(trifluoromethyl)phenyl]methyl}-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione | Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26F3N3O4S |
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| Mol. Mass. | 509.541 |
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| SMILES | CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O |r| |
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| Structure | 
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