| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Ligand | BDBM22466 |
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| Substrate/Competitor | BDBM13775 |
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| Meas. Tech. | Human 11beta-HSD1 Scintillation Proximity Assay (SPA) |
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| IC50 | >10000±n/a nM |
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| Citation |  Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice. J Med Chem51:2933-43 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 44141.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purified recombinant human 11beta-HSD2. |
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| Residue: | 405 |
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| Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
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| BDBM22466 |
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| BDBM13775 |
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| Name | BDBM22466 |
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| Synonyms: | 2-Amino-1,3-thiazol-4(5H)-one, 5h | 5-ethyl-5-methyl-2-{tricyclo[3.3.1.0^{3,7}]nonan-3-ylamino}-4,5-dihydro-1,3-thiazol-4-one |
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| Type | Small organic molecule |
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| Emp. Form. | C15H22N2OS |
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| Mol. Mass. | 278.413 |
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| SMILES | CCC1(C)SC(NC23CC4CC2CC(C3)C4)=NC1=O |c:18,TLB:14:13:7.8:10,6:7:10:13.12.15,6:7:12:9.10.15,THB:8:7:12:9.10.15,8:9:7.14:12,14:7:10:13.12.15| |
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| Structure | 
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