| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Ligand | BDBM356434 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescent Polarization Binding (FP Binding) assay |
|---|
| IC50 | 500±n/a nM |
|---|
| Citation |  Estrada, AA; Feng, JA; Fox, B; Sweeney, ZK Compounds, compositions and methods US Patent US9896458 Publication Date 2/20/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 75926.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13546 |
|---|
| Residue: | 671 |
|---|
| Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
|
|
|
|---|
| BDBM356434 |
|---|
| n/a |
|---|
| Name | BDBM356434 |
|---|
| Synonyms: | US10604535, Example 166 | US9815850, Compound 166 | US9896458, No. 166 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17F2N5O3 |
|---|
| Mol. Mass. | 413.3775 |
|---|
| SMILES | CN1c2ncccc2OC[C@H](NC(=O)c2cc(F)n(Cc3ccc(F)cc3)n2)C1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
