Reaction Details |
| Report a problem with these data |
Target | Prostaglandin G/H synthase 1 |
---|
Ligand | BDBM22979 |
---|
Substrate/Competitor | BDBM22319 |
---|
Meas. Tech. | Time-Dependent Inhibition Assay |
---|
pH | 8±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 1200±n/a nM |
---|
Citation | Kalgutkar, AS; Crews, BC; Rowlinson, SW; Marnett, AB; Kozak, KR; Remmel, RP; Marnett, LJ Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proc Natl Acad Sci U S A97:925-30 (2000) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Prostaglandin G/H synthase 1 |
---|
Name: | Prostaglandin G/H synthase 1 |
Synonyms: | COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
Type: | Protein |
Mol. Mass.: | 68868.60 |
Organism: | Ovis aries (Sheep) |
Description: | n/a |
Residue: | 600 |
Sequence: | MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVR
SNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRR
FLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLML
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
|
|
|
BDBM22979 |
---|
BDBM22319 |
---|
Name | BDBM22979 |
Synonyms: | CHEMBL148629 | Meclofenamic acid derivative, 31 | methyl 2-({2-[(2,6-dichloro-3-methylphenyl)amino]phenyl}formamido)acetate |
Type | Small organic molecule |
Emp. Form. | C17H16Cl2N2O3 |
Mol. Mass. | 367.227 |
SMILES | COC(=O)CNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl |
Structure |
|