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TargetFatty Acid Amide Hydrolase
LigandBDBM23069
Substrate/CompetitorBDBM23028
Meas. Tech.FAAH Inhibition Assay
Temperature298.15±n/a K
Ki 1.3±n/a nM
IC50 1±n/a nM
Commentsextracted
Citation Hardouin CKelso MJRomero FARayl TJLeung DHwang ICravatt BFBoger DL Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem 50:3359-68 (2007) [PubMed]  Article
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Fatty Acid Amide Hydrolase
Name:DNA Ligase I
Synonyms:ATP-dependent DNA ligase | Polydeoxyribonucleotide synthase [ATP]
Type:Enzyme
Mol. Mass.:101721.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:919
Sequence:
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKA
ARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK
RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ
PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK
KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIE
EVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST
AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM
VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPL
KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD
IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE
GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLL
ASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA
VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ
SQIQNQQGEDSGSDPEDTY
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  Blast E-value cutoff:
BDBM23069
BDBM23028
NameBDBM23069
Synonyms:3-[4-(benzyloxy)phenyl]-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]propan-1-one | alpha-ketooxazole, 11a
TypeSmall organic molecule
Emp. Form.C24H20N2O3
Mol. Mass.384.4272
SMILESO=C(CCc1ccc(OCc2ccccc2)cc1)c1ncc(o1)-c1ccccn1
Structure
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