Reaction Details |
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Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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Ligand | BDBM23589 |
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Substrate/Competitor | BDBM3158 |
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Meas. Tech. | FabD/FabH Coupled Assay |
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IC50 | 3200±n/a nM |
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Citation | Nie, Z; Perretta, C; Lu, J; Su, Y; Margosiak, S; Gajiwala, KS; Cortez, J; Nikulin, V; Yager, KM; Appelt, K; Chu, S Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents. J Med Chem48:1596-609 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
Synonyms: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III | FABH_ENTFA | KAS III | beta-Ketoacyl-ACP Synthase III (FabH) | fabH |
Type: | Acyltransferase; homodimer |
Mol. Mass.: | 35176.53 |
Organism: | Enterococcus faecalis |
Description: | The E. faecalis FabH was cloned, and protein was expressed in E. coli. |
Residue: | 321 |
Sequence: | MKNYARISCTSRYVPENCVTNHQLSEMMDTSDEWIHSRTGISERRIVTQENTSDLCHQVA
KQLLEKSGKQASEIDFILVATVTPDFNMPSVACQVQGAIGATEAFAFDISAACSGFVYAL
SMAEKLVLSGRYQTGLVIGGETFSKMLDWTDRSTAVLFGDGAAGVLIEAAETPHFLNEKL
QADGQRWAALTSGYTINESPFYQGHKQASKTLQMEGRSIFDFAIKDVSQNILSLVTDETV
DYLLLHQANVRIIDKIARKTKISREKFLTNMDKYGNTSAASIPILLDEAVENGTLILGSQ
QRVVLTGFGGGLTWGSLLLTL
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BDBM23589 |
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BDBM3158 |
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Name | BDBM23589 |
Synonyms: | (3-Phenoxybenzoylamino)benzoic acid deriv., 23f | 2-{[4-(morpholin-4-yl)-3-phenoxybenzene]amido}benzoic acid |
Type | Small organic molecule |
Emp. Form. | C24H22N2O5 |
Mol. Mass. | 418.4419 |
SMILES | OC(=O)c1ccccc1NC(=O)c1ccc(N2CCOCC2)c(Oc2ccccc2)c1 |
Structure |
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