| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytosol aminopeptidase |
|---|
| Ligand | BDBM23974 |
|---|
| Substrate/Competitor | BDBM23972 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| pH | 8±n/a |
|---|
| Temperature | 303.15±n/a K |
|---|
| IC50 | >1000000±n/a nM |
|---|
| Citation |  Albrecht, S; Defoin, A; Salomon, E; Tarnus, C; Wetterholm, A; Haeggström, JZ Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors. Bioorg Med Chem14:7241-57 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Cytosol aminopeptidase |
|---|
| Name: | Cytosol aminopeptidase |
|---|
| Synonyms: | AMPL_BOVIN | LAP | LAP3 | LAPc | Leucine Aminopeptidase | Leucyl aminopeptidase |
|---|
| Type: | Homohexamer |
|---|
| Mol. Mass.: | 56288.28 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | Bovine kidney LAPc was purchased from Sigma Chemical Co. |
|---|
| Residue: | 519 |
|---|
| Sequence: | MFLLPLPAAARVAVRHLSVKRLWAPGPAAADMTKGLVLGIYSKEKEEDEPQFTSAGENFN
KLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKEN
IRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGS
EDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKSWI
EEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGKGITFDSGGISIKAAANMD
LMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKTIQV
DNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFE
ASIETGDRVWRMPLFEHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHL
DIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQDSA
|
|
|
|---|
| BDBM23974 |
|---|
| BDBM23972 |
|---|
| Name | BDBM23974 |
|---|
| Synonyms: | (3Z)-3-(hydroxyimino)-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride | Tetralone-oxime derivative, 2a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H12N2O |
|---|
| Mol. Mass. | 176.2151 |
|---|
| SMILES | ONC1Cc2ccccc2CC1=N |
|---|
| Structure | 
|
|---|
Search and Browse
