Reaction Details |
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Target | Kinesin-like protein KIF11 |
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Ligand | BDBM24114 |
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Substrate/Competitor | BDBM2 |
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Meas. Tech. | Microtubule-Activated Eg5 ATPase Assay |
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pH | 7±n/a |
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Temperature | 296.15±n/a K |
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IC50 | 8880±n/a nM |
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Citation | Tarby, CM; Kaltenbach, RF; Huynh, T; Pudzianowski, A; Shen, H; Ortega-Nanos, M; Sheriff, S; Newitt, JA; McDonnell, PA; Burford, N; Fairchild, CR; Vaccaro, W; Chen, Z; Borzilleri, RM; Naglich, J; Lombardo, LJ; Gottardis, M; Trainor, GL; Roussell, DL Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series. Bioorg Med Chem Lett16:2095-100 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Kinesin-like protein KIF11 |
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Name: | Kinesin-like protein KIF11 |
Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein |
Type: | PROTEIN |
Mol. Mass.: | 119138.97 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1457426 |
Residue: | 1056 |
Sequence: | MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK
DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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BDBM24114 |
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BDBM2 |
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Name | BDBM24114 |
Synonyms: | [3-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]dimethylamine | tetrahydroisoquinoline (THIQ), 19 |
Type | Small organic molecule |
Emp. Form. | C22H30N2 |
Mol. Mass. | 322.487 |
SMILES | CN(C)CCCN1CC(c2ccccc2)c2ccc(C)c(C)c2C1 |
Structure |
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