| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF11 |
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| Ligand | BDBM24131 |
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| Substrate/Competitor | BDBM2 |
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| Meas. Tech. | Microtubule-Activated Eg5 ATPase Assay |
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| IC50 | 3480±n/a nM |
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| Citation |  Tarby, CM; Kaltenbach, RF; Huynh, T; Pudzianowski, A; Shen, H; Ortega-Nanos, M; Sheriff, S; Newitt, JA; McDonnell, PA; Burford, N; Fairchild, CR; Vaccaro, W; Chen, Z; Borzilleri, RM; Naglich, J; Lombardo, LJ; Gottardis, M; Trainor, GL; Roussell, DL Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series. Bioorg Med Chem Lett16:2095-100 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Kinesin-like protein KIF11 |
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| Name: | Kinesin-like protein KIF11 |
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| Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 119138.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1457426 |
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| Residue: | 1056 |
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| Sequence: | MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK
DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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| BDBM24131 |
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| BDBM2 |
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| Name | BDBM24131 |
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| Synonyms: | 4-(3-chlorophenyl)-N,N,7,8-tetramethyl-1,2,3,4-tetrahydroisoquinoline-2-carboxamide | tetrahydroisoquinoline (THIQ), 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23ClN2O |
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| Mol. Mass. | 342.862 |
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| SMILES | CN(C)C(=O)N1CC(c2cccc(Cl)c2)c2ccc(C)c(C)c2C1 |
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| Structure | 
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