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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM380544 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| IC50 | 15.0±n/a nM | ||
| Citation |  Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent US9926330 Publication Date 3/27/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM380544 | |||
| n/a | |||
| Name | BDBM380544 | ||
| Synonyms: | N-(trans-4-morpholin-4-ylcyclohexyl)- 6-(trifluoromethyl)quinazolin-4-amine | US9926330, 1-4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H23F3N4O | ||
| Mol. Mass. | 380.4073 | ||
| SMILES | FC(F)(F)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:13.12,wD:16.19,(-4.85,6.19,;-3.76,5.1,;-2.27,5.5,;-3.36,6.59,;-4.16,3.61,;-5.64,3.21,;-6.04,1.73,;-4.95,.64,;-5.35,-.85,;-4.26,-1.94,;-2.78,-1.54,;-2.38,-.05,;-.89,.35,;.2,-.74,;1.69,-.35,;2.78,-1.43,;2.38,-2.92,;.89,-3.32,;-.2,-2.23,;3.47,-4.01,;3.07,-5.5,;4.16,-6.59,;5.64,-6.19,;6.04,-4.7,;4.95,-3.61,;-3.47,1.04,;-3.07,2.52,)| | ||
| Structure | 
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