| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM24796 |
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| Substrate/Competitor | BDBM21974 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | 4950±n/a nM |
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| Citation |  Kumar, S; Malachowski, WP; DuHadaway, JB; LaLonde, JM; Carroll, PJ; Jaller, D; Metz, R; Prendergast, GC; Muller, AJ Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem51:1706-18 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM24796 |
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| BDBM21974 |
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| Name | BDBM24796 |
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| Synonyms: | (11S,13S)-14,14-dimethyl-12,15-dioxatetracyclo[8.5.0.0^{3,8}.0^{11,13}]pentadeca-1(10),3(8),4,6-tetraene-2,9-dione | Pyranonaphthoquinone derivative, 33 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12O4 |
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| Mol. Mass. | 256.2534 |
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| SMILES | CC1(C)OC2=C([C@@H]3O[C@H]13)C(=O)c1ccccc1C2=O |r,c:4| |
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| Structure | 
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