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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM24799
Substrate/CompetitorBDBM21974
Meas. Tech.Enzyme Inhibition Assay
IC50 186±n/a nM
Citation Kumar SMalachowski WPDuHadaway JBLaLonde JMCarroll PJJaller DMetz RPrendergast GCMuller AJ Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem 51:1706-18 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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  Blast E-value cutoff:
BDBM24799
BDBM21974
NameBDBM24799
Synonyms:(3S,4S)-3-hydroxy-2,2-dimethyl-4-(prop-2-en-1-ylamino)-2H,3H,4H,5H,10H-naphtho[2,3-b]pyran-5,10-dione | Pyranonaphthoquinone derivative, 38
TypeSmall organic molecule
Emp. Form.C18H19NO4
Mol. Mass.313.3478
SMILESCC1(C)OC2=C([C@H](NCC=C)[C@@H]1O)C(=O)c1ccccc1C2=O |r,c:4|
Structure
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