| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
|---|
| Ligand | BDBM381126 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Binding Assay |
|---|
| IC50 | 21.0±n/a nM |
|---|
| Citation |  Fyfe, MC; Thom, SM; Baker, TM; Harbottle, GW; Hasimbegovic, V; Rigby, A Urea derivatives useful as kinase inhibitors US Patent US9890185 Publication Date 2/13/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 14 |
|---|
| Name: | Mitogen-activated protein kinase 14 |
|---|
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 41286.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16539 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
|
|
|
|---|
| BDBM381126 |
|---|
| n/a |
|---|
| Name | BDBM381126 |
|---|
| Synonyms: | 3-((4-((4-(3-(3-(2-Amino-2-oxoethyl)-5-(tert-butyl)-2-methoxyphenyl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(2-morpholinoethyl)benzamide | US9890185, Example 45 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C43H49N7O7 |
|---|
| Mol. Mass. | 775.8919 |
|---|
| SMILES | COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CC(N)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
