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Compile Data Set for Download or QSAR

Found 852 hits with Last Name = 'hasimbegovic' and Initial = 'v'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM381166
PNG
(US9890185, Example 79(g))
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)=O)C(C)(C)C)c4ccccc34)ccn2)ccc1C(O)=O
Show InChI InChI=1S/C36H36N4O7S/c1-36(2,3)21-17-28(33(46-5)31(18-21)48(6)44)40-35(43)39-27-13-14-29(25-10-8-7-9-24(25)27)47-23-15-16-37-32(20-23)38-22-11-12-26(34(41)42)30(19-22)45-4/h7-20H,1-6H3,(H,37,38)(H,41,42)(H2,39,40,43)
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n/an/a 5n/an/an/an/an/an/a



Cephalon



Assay Description
Method 2: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to t...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381082
PNG
(US9890185, Example 38(e))
Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(NCc4ccccn4)c3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C
Show InChI InChI=1S/C35H38N5O4P/c1-35(2,3)23-19-29(33(43-4)31(20-23)45(5,6)42)40-34(41)39-28-14-15-30(27-13-8-7-12-26(27)28)44-25-16-18-37-32(21-25)38-22-24-11-9-10-17-36-24/h7-21H,22H2,1-6H3,(H,37,38)(H2,39,40,41)
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n/an/a 5n/an/an/an/an/an/a



Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381094
PNG
(US9890185, Example 38(q))
Show SMILES COc1c(CNC(C)=O)cc(cc1NC(=O)Nc1ccc(Oc2ccnc(NCc3ccccn3)c2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H38N6O4/c1-23(43)39-21-24-18-25(36(2,3)4)19-31(34(24)45-5)42-35(44)41-30-13-14-32(29-12-7-6-11-28(29)30)46-27-15-17-38-33(20-27)40-22-26-10-8-9-16-37-26/h6-20H,21-22H2,1-5H3,(H,38,40)(H,39,43)(H2,41,42,44)
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n/an/a 6n/an/an/an/an/an/a



Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256521
PNG
(US10435361, Example 20 | US9481648, 20 | US9790174...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(C(N)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C41H48N6O9/c1-41(2,3)26-21-32(38(42)48)37(52-6)34(22-26)46-40(49)45-33-11-12-35(31-10-8-7-9-30(31)33)56-36-13-14-43-39(47-36)44-27-23-28(51-5)25-29(24-27)55-20-19-54-18-17-53-16-15-50-4/h7-14,21-25H,15-20H2,1-6H3,(H2,42,48)(H,43,44,47)(H2,45,46,49)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381071
PNG
(1-(5-(tert-Butyl)-3-(dimethylphosphoryl)-2-methoxy...)
Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(NCc4ccccn4)n3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C
Show InChI InChI=1S/C34H37N6O4P/c1-34(2,3)22-19-27(31(43-4)29(20-22)45(5,6)42)39-33(41)38-26-14-15-28(25-13-8-7-12-24(25)26)44-30-16-18-36-32(40-30)37-21-23-11-9-10-17-35-23/h7-20H,21H2,1-6H3,(H,36,37,40)(H2,38,39,41)
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Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381167
PNG
(US9890185, Example 79(m))
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)P(C)(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(c1)S(=O)(=O)N(C)CCN1CCN(C)CC1
Show InChI InChI=1S/C44H56N7O7PS/c1-44(2,3)30-24-38(42(57-7)40(25-30)59(8,9)53)48-43(52)47-37-14-15-39(36-13-11-10-12-35(36)37)58-32-16-17-45-41(29-32)46-31-26-33(56-6)28-34(27-31)60(54,55)50(5)20-23-51-21-18-49(4)19-22-51/h10-17,24-29H,18-23H2,1-9H3,(H,45,46)(H2,47,48,52)
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n/an/a 6n/an/an/an/an/an/a



Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM381167
PNG
(US9890185, Example 79(m))
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)P(C)(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(c1)S(=O)(=O)N(C)CCN1CCN(C)CC1
Show InChI InChI=1S/C44H56N7O7PS/c1-44(2,3)30-24-38(42(57-7)40(25-30)59(8,9)53)48-43(52)47-37-14-15-39(36-13-11-10-12-35(36)37)58-32-16-17-45-41(29-32)46-31-26-33(56-6)28-34(27-31)60(54,55)50(5)20-23-51-21-18-49(4)19-22-51/h10-17,24-29H,18-23H2,1-9H3,(H,45,46)(H2,47,48,52)
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n/an/a 7n/an/an/an/an/an/a



Cephalon



Assay Description
Method 2: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to t...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256511
PNG
(US10435361, Example 9 | US9481648, 9 | US9790174, ...)
Show SMILES CNC(=O)c1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(cc(c4)C(=O)NCCN4CCOCC4)C#C)n3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C43H46N8O6/c1-7-27-22-28(39(52)45-16-17-51-18-20-56-21-19-51)24-30(23-27)47-41-46-15-14-37(50-41)57-36-13-12-34(31-10-8-9-11-32(31)36)48-42(54)49-35-26-29(43(2,3)4)25-33(38(35)55-6)40(53)44-5/h1,8-15,22-26H,16-21H2,2-6H3,(H,44,53)(H,45,52)(H,46,47,50)(H2,48,49,54)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381123
PNG
(1-(5-(tert-Butyl)-2-methoxy-3-(methylsulfinyl)phen...)
Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(NCc4ccccn4)c3)c3ccccc23)cc(cc1S(C)=O)C(C)(C)C
Show InChI InChI=1S/C34H35N5O4S/c1-34(2,3)22-18-28(32(42-4)30(19-22)44(5)41)39-33(40)38-27-13-14-29(26-12-7-6-11-25(26)27)43-24-15-17-36-31(20-24)37-21-23-10-8-9-16-35-23/h6-20H,21H2,1-5H3,(H,36,37)(H2,38,39,40)
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Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM347466
PNG
(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Show SMILES CNc1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(c4)C(=O)NCCOCCOCCOC)n3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C42H51N7O8/c1-42(2,3)28-24-34(43-4)38(54-7)35(25-28)48-41(51)47-33-12-13-36(32-11-9-8-10-31(32)33)57-37-14-15-45-40(49-37)46-29-22-27(23-30(26-29)53-6)39(50)44-16-17-55-20-21-56-19-18-52-5/h8-15,22-26,43H,16-21H2,1-7H3,(H,44,50)(H,45,46,49)(H2,47,48,51)
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n/an/a 9n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
TBD

US Patent US10435361 (2019)


BindingDB Entry DOI: 10.7270/Q25M6839
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381084
PNG
(US9890185, Example 38(g))
Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(NCc4ccccc4)n3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C
Show InChI InChI=1S/C35H38N5O4P/c1-35(2,3)24-20-28(32(43-4)30(21-24)45(5,6)42)39-34(41)38-27-16-17-29(26-15-11-10-14-25(26)27)44-31-18-19-36-33(40-31)37-22-23-12-8-7-9-13-23/h7-21H,22H2,1-6H3,(H,36,37,40)(H2,38,39,41)
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Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256515
PNG
(US10435361, Example 13 | US9481648, 13 | US9790174...)
Show SMILES CNC(=O)c1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCCOC)c4)n3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C42H50N6O9/c1-42(2,3)27-22-33(39(49)43-4)38(53-7)35(23-27)47-41(50)46-34-12-13-36(32-11-9-8-10-31(32)34)57-37-14-15-44-40(48-37)45-28-24-29(52-6)26-30(25-28)56-21-20-55-19-18-54-17-16-51-5/h8-15,22-26H,16-21H2,1-7H3,(H,43,49)(H,44,45,48)(H2,46,47,50)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM380997
PNG
(US9890185, Example 1)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)P(C)(C)=O)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C42H52N5O9P/c1-42(2,3)28-23-35(39(52-6)37(24-28)57(7,8)49)46-41(48)45-34-13-14-36(33-12-10-9-11-32(33)34)56-38-15-16-43-40(47-38)44-29-25-30(51-5)27-31(26-29)55-22-21-54-20-19-53-18-17-50-4/h9-16,23-27H,17-22H2,1-8H3,(H,43,44,47)(H2,45,46,48)
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Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256509
PNG
(US9481648, 7)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C42H51N7O10S/c1-42(2,3)28-24-34(38(56-6)35(25-28)49-60(7,52)53)47-41(51)46-33-12-13-36(32-11-9-8-10-31(32)33)59-37-14-15-44-40(48-37)45-29-22-27(23-30(26-29)55-5)39(50)43-16-17-57-20-21-58-19-18-54-4/h8-15,22-26,49H,16-21H2,1-7H3,(H,43,50)(H,44,45,48)(H2,46,47,51)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381092
PNG
(US9890185, Example 38(o))
Show SMILES COc1c(CC(N)=O)cc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccn(C)n3)c2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C33H35N7O4/c1-33(2,3)21-16-20(17-28(34)41)31(43-5)26(18-21)37-32(42)36-25-10-11-27(24-9-7-6-8-23(24)25)44-22-12-14-35-30(19-22)38-29-13-15-40(4)39-29/h6-16,18-19H,17H2,1-5H3,(H2,34,41)(H,35,38,39)(H2,36,37,42)
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Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256519
PNG
(US10435361, Example 18 | US9481648, 18 | US9790174...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCCN2CCOCC2)c1
Show InChI InChI=1S/C44H55N7O10S/c1-44(2,3)30-25-37(41(56-5)38(26-30)50-62(6,53)54)48-43(52)47-36-11-12-39(35-10-8-7-9-34(35)36)61-40-13-14-45-42(49-40)46-31-27-32(55-4)29-33(28-31)60-24-23-59-22-21-58-20-17-51-15-18-57-19-16-51/h7-14,25-29,50H,15-24H2,1-6H3,(H,45,46,49)(H2,47,48,52)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM347465
PNG
(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Show SMILES CNc1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(c4)C(=O)NCCN4CCOCC4)n3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C41H48N8O6/c1-41(2,3)27-23-33(42-4)37(53-6)34(24-27)47-40(51)46-32-11-12-35(31-10-8-7-9-30(31)32)55-36-13-14-44-39(48-36)45-28-21-26(22-29(25-28)52-5)38(50)43-15-16-49-17-19-54-20-18-49/h7-14,21-25,42H,15-20H2,1-6H3,(H,43,50)(H,44,45,48)(H2,46,47,51)
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n/an/a 11n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
TBD

US Patent US10435361 (2019)


BindingDB Entry DOI: 10.7270/Q25M6839
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM380998
PNG
(1-(5-(tert-Butyl)-3-(dimethylphosphoryl)-2-methoxy...)
Show SMILES COCCOCCOCCOc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)P(C)(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C43H53N4O9P/c1-43(2,3)29-23-37(41(52-6)39(24-29)57(7,8)49)47-42(48)46-36-13-14-38(35-12-10-9-11-34(35)36)56-31-15-16-44-40(28-31)45-30-25-32(51-5)27-33(26-30)55-22-21-54-20-19-53-18-17-50-4/h9-16,23-28H,17-22H2,1-8H3,(H,44,45)(H2,46,47,48)
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Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM256524
PNG
(US10435361, Example 23 | US9481648, 23 | US9790174...)
Show SMILES CNC(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCCOC)c4)n3)c3ccccc23)cc(c1)C(C)(C)C
Show InChI InChI=1S/C41H48N6O8/c1-41(2,3)28-21-27(38(48)42-4)22-29(23-28)45-40(49)46-35-11-12-36(34-10-8-7-9-33(34)35)55-37-13-14-43-39(47-37)44-30-24-31(51-6)26-32(25-30)54-20-19-53-18-17-52-16-15-50-5/h7-14,21-26H,15-20H2,1-6H3,(H,42,48)(H,43,44,47)(H2,45,46,49)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
Method 2: This method follows the same steps as Method 1 above, but utilises a higher concentration of the p38 MAPKα protein (2.5 uL of 200 ng/...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256534
PNG
(US10435361, Example 33 | US9481648, 33 | US9790174...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(C(=O)NC5CC5)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C44H52N6O9/c1-44(2,3)28-23-35(41(51)46-29-11-12-29)40(55-6)37(24-28)49-43(52)48-36-13-14-38(34-10-8-7-9-33(34)36)59-39-15-16-45-42(50-39)47-30-25-31(54-5)27-32(26-30)58-22-21-57-20-19-56-18-17-53-4/h7-10,13-16,23-27,29H,11-12,17-22H2,1-6H3,(H,46,51)(H,45,47,50)(H2,48,49,52)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256516
PNG
(US10435361, Example 14 | US9481648, 14 | US9790174...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C49H66N6O14S/c1-49(2,3)35-30-42(46(61-6)43(31-35)55-70(7,57)58)53-48(56)52-41-12-13-44(40-11-9-8-10-39(40)41)69-45-14-15-50-47(54-45)51-36-32-37(60-5)34-38(33-36)68-29-28-67-27-26-66-25-24-65-23-22-64-21-20-63-19-18-62-17-16-59-4/h8-15,30-34,55H,16-29H2,1-7H3,(H,50,51,54)(H2,52,53,56)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256524
PNG
(US10435361, Example 23 | US9481648, 23 | US9790174...)
Show SMILES CNC(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCCOC)c4)n3)c3ccccc23)cc(c1)C(C)(C)C
Show InChI InChI=1S/C41H48N6O8/c1-41(2,3)28-21-27(38(48)42-4)22-29(23-28)45-40(49)46-35-11-12-36(34-10-8-7-9-33(34)35)55-37-13-14-43-39(47-37)44-30-24-31(51-6)26-32(25-30)54-20-19-53-18-17-52-16-15-50-5/h7-14,21-26H,15-20H2,1-6H3,(H,42,48)(H,43,44,47)(H2,45,46,49)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256508
PNG
(US9481648, 6)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(c1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C41H48N8O8S/c1-41(2,3)27-23-33(37(55-5)34(24-27)48-58(6,52)53)46-40(51)45-32-11-12-35(31-10-8-7-9-30(31)32)57-36-13-14-43-39(47-36)44-28-21-26(22-29(25-28)54-4)38(50)42-15-16-49-17-19-56-20-18-49/h7-14,21-25,48H,15-20H2,1-6H3,(H,42,50)(H,43,44,47)(H2,45,46,51)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381080
PNG
(US9890185, Example 38(c))
Show SMILES COc1cc(CO)cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)P(C)(C)=O)C(C)(C)C)c4ccccc34)ccn2)c1
Show InChI InChI=1S/C37H41N4O6P/c1-37(2,3)24-18-31(35(46-5)33(19-24)48(6,7)44)41-36(43)40-30-12-13-32(29-11-9-8-10-28(29)30)47-26-14-15-38-34(21-26)39-25-16-23(22-42)17-27(20-25)45-4/h8-21,42H,22H2,1-7H3,(H,38,39)(H2,40,41,43)
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n/an/a 12n/an/an/an/an/an/a



Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381126
PNG
(3-((4-((4-(3-(3-(2-Amino-2-oxoethyl)-5-(tert-butyl...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CC(N)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C43H49N7O7/c1-43(2,3)29-20-27(23-38(44)51)40(55-5)36(24-29)49-42(53)48-35-10-11-37(34-9-7-6-8-33(34)35)57-31-12-13-45-39(26-31)47-30-21-28(22-32(25-30)54-4)41(52)46-14-15-50-16-18-56-19-17-50/h6-13,20-22,24-26H,14-19,23H2,1-5H3,(H2,44,51)(H,45,47)(H,46,52)(H2,48,49,53)
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Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381134
PNG
(3-((4-((4-(3-(3-(2-Amino-2-oxoethyl)-5-(tert-butyl...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CC(N)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C44H52N6O9/c1-44(2,3)30-21-28(24-39(45)51)41(56-6)37(25-30)50-43(53)49-36-11-12-38(35-10-8-7-9-34(35)36)59-32-13-14-46-40(27-32)48-31-22-29(23-33(26-31)55-5)42(52)47-15-16-57-19-20-58-18-17-54-4/h7-14,21-23,25-27H,15-20,24H2,1-6H3,(H2,45,51)(H,46,48)(H,47,52)(H2,49,50,53)
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Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256538
PNG
(US10435361, Example 37 | US9481648, 37 | US9790174...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(C(=O)NCC(=O)OC)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C44H52N6O11/c1-44(2,3)28-22-34(41(52)46-27-39(51)56-6)40(57-7)36(23-28)49-43(53)48-35-12-13-37(33-11-9-8-10-32(33)35)61-38-14-15-45-42(50-38)47-29-24-30(55-5)26-31(25-29)60-21-20-59-19-18-58-17-16-54-4/h8-15,22-26H,16-21,27H2,1-7H3,(H,46,52)(H,45,47,50)(H2,48,49,53)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381150
PNG
(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCS(=O)CC1
Show InChI InChI=1S/C42H48N6O7S2/c1-42(2,3)28-23-35(39(54-5)37(24-28)56(6)51)47-41(50)46-34-11-12-36(33-10-8-7-9-32(33)34)55-30-13-14-43-38(26-30)45-29-21-27(22-31(25-29)53-4)40(49)44-15-16-48-17-19-57(52)20-18-48/h7-14,21-26H,15-20H2,1-6H3,(H,43,45)(H,44,49)(H2,46,47,50)
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Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256503
PNG
(US9481648, 1 | US9790174, Example 1)
Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(cc(c4)C(=O)NCCN4CCOCC4)C#C)n3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C42H46N8O7S/c1-7-27-22-28(39(51)43-16-17-50-18-20-56-21-19-50)24-30(23-27)45-40-44-15-14-37(48-40)57-36-13-12-33(31-10-8-9-11-32(31)36)46-41(52)47-34-25-29(42(2,3)4)26-35(38(34)55-5)49-58(6,53)54/h1,8-15,22-26,49H,16-21H2,2-6H3,(H,43,51)(H,44,45,48)(H2,46,47,52)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM414113
PNG
(US10435361, Example 1)
Show SMILES CNc1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(cc(c4)C(=O)NCCN4CCOCC4)C#C)n3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C42H46N8O5/c1-7-27-22-28(39(51)44-16-17-50-18-20-54-21-19-50)24-30(23-27)46-40-45-15-14-37(49-40)55-36-13-12-33(31-10-8-9-11-32(31)36)47-41(52)48-35-26-29(42(2,3)4)25-34(43-5)38(35)53-6/h1,8-15,22-26,43H,16-21H2,2-6H3,(H,44,51)(H,45,46,49)(H2,47,48,52)
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Topivert Pharma Limited

US Patent


Assay Description
TBD

US Patent US10435361 (2019)


BindingDB Entry DOI: 10.7270/Q25M6839
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381081
PNG
(US9890185, Example 38(d))
Show SMILES COc1c(CC(N)=O)cc(cc1NC(=O)Nc1ccc(Oc2ccnc(NCc3ccccn3)c2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H36N6O4/c1-35(2,3)23-17-22(18-31(36)42)33(44-4)29(19-23)41-34(43)40-28-12-13-30(27-11-6-5-10-26(27)28)45-25-14-16-38-32(20-25)39-21-24-9-7-8-15-37-24/h5-17,19-20H,18,21H2,1-4H3,(H2,36,42)(H,38,39)(H2,40,41,43)
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n/an/a 13n/an/an/an/an/an/a



Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381098
PNG
(US9890185, Example 38(u))
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CS(C)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C43H50N6O7S/c1-43(2,3)30-21-29(27-57(6)52)40(54-5)37(24-30)48-42(51)47-36-11-12-38(35-10-8-7-9-34(35)36)56-32-13-14-44-39(26-32)46-31-22-28(23-33(25-31)53-4)41(50)45-15-16-49-17-19-55-20-18-49/h7-14,21-26H,15-20,27H2,1-6H3,(H,44,46)(H,45,50)(H2,47,48,51)
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Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256536
PNG
(US10435361, Example 35 | US9481648, 35 | US9790174...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(C(=O)NCCO)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C43H52N6O10/c1-43(2,3)28-23-34(40(51)44-15-16-50)39(55-6)36(24-28)48-42(52)47-35-11-12-37(33-10-8-7-9-32(33)35)59-38-13-14-45-41(49-38)46-29-25-30(54-5)27-31(26-29)58-22-21-57-20-19-56-18-17-53-4/h7-14,23-27,50H,15-22H2,1-6H3,(H,44,51)(H,45,46,49)(H2,47,48,52)
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n/an/a 13n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381149
PNG
(3-((4-((4-(3-(3-(2-Amino-2-oxoethyl)-5-(tert-butyl...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CC(N)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCCN1CCS(=O)CC1
Show InChI InChI=1S/C44H51N7O7S/c1-44(2,3)30-21-28(24-39(45)52)41(57-5)37(25-30)50-43(54)49-36-11-12-38(35-10-7-6-9-34(35)36)58-32-13-15-46-40(27-32)48-31-22-29(23-33(26-31)56-4)42(53)47-14-8-16-51-17-19-59(55)20-18-51/h6-7,9-13,15,21-23,25-27H,8,14,16-20,24H2,1-5H3,(H2,45,52)(H,46,48)(H,47,53)(H2,49,50,54)
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Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256570
PNG
(US10435361, Example 69 | US9481648, 69 | US9790174...)
Show SMILES CCOc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCCOC)c4)n3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C42H52N6O10S/c1-8-56-39-35(23-28(42(2,3)4)24-36(39)48-59(7,50)51)46-41(49)45-34-13-14-37(33-12-10-9-11-32(33)34)58-38-15-16-43-40(47-38)44-29-25-30(53-6)27-31(26-29)57-22-21-55-20-19-54-18-17-52-5/h9-16,23-27,48H,8,17-22H2,1-7H3,(H,43,44,47)(H2,45,46,49)
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n/an/a 13n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM347463
PNG
(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Show SMILES CNc1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCCOC)c4)n3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C41H50N6O8/c1-41(2,3)27-22-34(42-4)38(51-7)35(23-27)46-40(48)45-33-12-13-36(32-11-9-8-10-31(32)33)55-37-14-15-43-39(47-37)44-28-24-29(50-6)26-30(25-28)54-21-20-53-19-18-52-17-16-49-5/h8-15,22-26,42H,16-21H2,1-7H3,(H,43,44,47)(H2,45,46,48)
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n/an/a 14n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
TBD

US Patent US10435361 (2019)


BindingDB Entry DOI: 10.7270/Q25M6839
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381152
PNG
(3-((4-((4-(3-(3-(Acetamidomethyl)-5-(tert-butyl)-2...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CNC(C)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCS(=O)CC1
Show InChI InChI=1S/C44H51N7O7S/c1-28(52)47-27-30-21-31(44(2,3)4)24-38(41(30)57-6)50-43(54)49-37-11-12-39(36-10-8-7-9-35(36)37)58-33-13-14-45-40(26-33)48-32-22-29(23-34(25-32)56-5)42(53)46-15-16-51-17-19-59(55)20-18-51/h7-14,21-26H,15-20,27H2,1-6H3,(H,45,48)(H,46,53)(H,47,52)(H2,49,50,54)
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n/an/a 14n/an/an/an/an/an/a



Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256525
PNG
(US10435361, Example 24 | US9481648, 24 | US9790174...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(NS(C)(=O)=O)cc(c4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C40H48N6O9S/c1-40(2,3)27-21-28(23-30(22-27)46-56(6,48)49)43-39(47)44-35-11-12-36(34-10-8-7-9-33(34)35)55-37-13-14-41-38(45-37)42-29-24-31(51-5)26-32(25-29)54-20-19-53-18-17-52-16-15-50-4/h7-14,21-26,46H,15-20H2,1-6H3,(H,41,42,45)(H2,43,44,47)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381012
PNG
(US9890185, Example 15(b))
Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C
Show InChI InChI=1S/C34H36N5O4P/c1-34(2,3)22-20-27(31(42-4)29(21-22)44(5,6)41)38-33(40)37-26-16-17-28(25-15-11-10-14-24(25)26)43-30-18-19-35-32(39-30)36-23-12-8-7-9-13-23/h7-21H,1-6H3,(H,35,36,39)(H2,37,38,40)
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Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256506
PNG
(US9481648, 4)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C41H50N6O10S/c1-41(2,3)27-22-34(38(53-6)35(23-27)47-58(7,49)50)45-40(48)44-33-12-13-36(32-11-9-8-10-31(32)33)57-37-14-15-42-39(46-37)43-28-24-29(52-5)26-30(25-28)56-21-20-55-19-18-54-17-16-51-4/h8-15,22-26,47H,16-21H2,1-7H3,(H,42,43,46)(H2,44,45,48)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381004
PNG
(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methoxy-5...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(C(=O)NCCN5CCOCC5)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C47H59N7O10/c1-47(2,3)32-27-38(44(55)48-15-16-54-17-19-60-20-18-54)43(59-6)40(28-32)52-46(56)51-39-11-12-41(37-10-8-7-9-36(37)39)64-42-13-14-49-45(53-42)50-33-29-34(58-5)31-35(30-33)63-26-25-62-24-23-61-22-21-57-4/h7-14,27-31H,15-26H2,1-6H3,(H,48,55)(H,49,50,53)(H2,51,52,56)
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Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM381098
PNG
(US9890185, Example 38(u))
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CS(C)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C43H50N6O7S/c1-43(2,3)30-21-29(27-57(6)52)40(54-5)37(24-30)48-42(51)47-36-11-12-38(35-10-8-7-9-34(35)36)56-32-13-14-44-39(26-32)46-31-22-28(23-33(25-31)53-4)41(50)45-15-16-49-17-19-55-20-18-49/h7-14,21-26H,15-20,27H2,1-6H3,(H,44,46)(H,45,50)(H2,47,48,51)
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Cephalon



Assay Description
Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381102
PNG
(US9890185, Example 38(y))
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CNC(C)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C45H54N6O9/c1-29(52)48-28-31-22-32(45(2,3)4)25-39(42(31)57-7)51-44(54)50-38-12-13-40(37-11-9-8-10-36(37)38)60-34-14-15-46-41(27-34)49-33-23-30(24-35(26-33)56-6)43(53)47-16-17-58-20-21-59-19-18-55-5/h8-15,22-27H,16-21,28H2,1-7H3,(H,46,49)(H,47,53)(H,48,52)(H2,50,51,54)
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Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381057
PNG
(1-(5-(tert-Butyl)-3-(dimethylphosphoryl)-2-methoxy...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)P(C)(C)=O)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C36H40N5O6P/c1-36(2,3)22-17-29(33(46-6)31(18-22)48(7,8)43)40-35(42)39-28-13-14-30(27-12-10-9-11-26(27)28)47-32-15-16-37-34(41-32)38-23-19-24(44-4)21-25(20-23)45-5/h9-21H,1-8H3,(H,37,38,41)(H2,39,40,42)
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Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256552
PNG
(US10435361, Example 51 | US9481648, 51 | US9790174...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(C(=O)NC5COC5)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C44H52N6O10/c1-44(2,3)28-21-35(41(51)46-30-26-58-27-30)40(55-6)37(22-28)49-43(52)48-36-11-12-38(34-10-8-7-9-33(34)36)60-39-13-14-45-42(50-39)47-29-23-31(54-5)25-32(24-29)59-20-19-57-18-17-56-16-15-53-4/h7-14,21-25,30H,15-20,26-27H2,1-6H3,(H,46,51)(H,45,47,50)(H2,48,49,52)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256547
PNG
(US10435361, Example 46 | US9481648, 46 | US9790174...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(C(=O)NCCN(C)C)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C45H57N7O9/c1-45(2,3)30-25-36(42(53)46-17-18-52(4)5)41(57-8)38(26-30)50-44(54)49-37-13-14-39(35-12-10-9-11-34(35)37)61-40-15-16-47-43(51-40)48-31-27-32(56-7)29-33(28-31)60-24-23-59-22-21-58-20-19-55-6/h9-16,25-29H,17-24H2,1-8H3,(H,46,53)(H,47,48,51)(H2,49,50,54)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM256548
PNG
(US10435361, Example 47 | US9481648, 47 | US9790174...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(C(N)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C42H47N7O7/c1-42(2,3)27-22-33(39(43)50)38(54-5)35(23-27)48-41(52)47-34-10-11-36(32-9-7-6-8-31(32)34)56-29-12-13-44-37(25-29)46-28-20-26(21-30(24-28)53-4)40(51)45-14-15-49-16-18-55-19-17-49/h6-13,20-25H,14-19H2,1-5H3,(H2,43,50)(H,44,46)(H,45,51)(H2,47,48,52)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US9481648 (2016)


BindingDB Entry DOI: 10.7270/Q24F1PNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381146
PNG
(3-((4-((4-(3-(3-(2-Amino-2-oxoethyl)-5-(tert-butyl...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CC(N)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCS(=O)CC1
Show InChI InChI=1S/C43H49N7O7S/c1-43(2,3)29-20-27(23-38(44)51)40(56-5)36(24-29)49-42(53)48-35-10-11-37(34-9-7-6-8-33(34)35)57-31-12-13-45-39(26-31)47-30-21-28(22-32(25-30)55-4)41(52)46-14-15-50-16-18-58(54)19-17-50/h6-13,20-22,24-26H,14-19,23H2,1-5H3,(H2,44,51)(H,45,47)(H,46,52)(H2,48,49,53)
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n/an/a 15n/an/an/an/an/an/a



Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381002
PNG
(1-(5-(tert-Butyl)-3-((dimethylphosphoryl)methoxy)-...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(OCP(C)(C)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C43H54N5O10P/c1-43(2,3)29-23-36(40(53-6)38(24-29)57-28-59(7,8)50)47-42(49)46-35-13-14-37(34-12-10-9-11-33(34)35)58-39-15-16-44-41(48-39)45-30-25-31(52-5)27-32(26-30)56-22-21-55-20-19-54-18-17-51-4/h9-16,23-27H,17-22,28H2,1-8H3,(H,44,45,48)(H2,46,47,49)
PDB
MMDB

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UniProtKB/SwissProt

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n/an/a 16n/an/an/an/an/an/a



Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM381006
PNG
(1-(3-(tert-Butyl)-5-(dimethylphosphoryl)phenyl)-3-...)
Show SMILES COCCOCCOCCOc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4)P(C)(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C42H51N4O8P/c1-42(2,3)29-22-30(26-35(23-29)55(6,7)48)45-41(47)46-38-12-13-39(37-11-9-8-10-36(37)38)54-32-14-15-43-40(28-32)44-31-24-33(50-5)27-34(25-31)53-21-20-52-19-18-51-17-16-49-4/h8-15,22-28H,16-21H2,1-7H3,(H,43,44)(H2,45,46,47)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Cephalon



Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

J Med Chem 51: 5680-9 (2008)


BindingDB Entry DOI: 10.7270/Q2FB558N
More data for this
Ligand-Target Pair
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