| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-ACP reductase |
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| Ligand | BDBM25403 |
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| Substrate/Competitor | BDBM8737 |
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| Meas. Tech. | PfENR Enzymatic Inhibition Assay |
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| pH | 7.9±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 49±20 nM |
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| Citation |  Freundlich, JS; Wang, F; Tsai, HC; Kuo, M; Shieh, HM; Anderson, JW; Nkrumah, LJ; Valderramos, JC; Yu, M; Kumar, TR; Valderramos, SG; Jacobs, WR; Schiehser, GA; Jacobus, DP; Fidock, DA; Sacchettini, JC X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy. J Biol Chem282:25436-44 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Enoyl-ACP reductase |
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| Name: | Enoyl-ACP reductase |
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| Synonyms: | Enoyl-ACP Reductase (PfENR) | Enoyl-ACP reductase |
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| Type: | Enzyme |
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| Mol. Mass.: | 49844.02 |
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| Organism: | Plasmodium falciparum |
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| Description: | Q9BJJ9 |
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| Residue: | 432 |
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| Sequence: | MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNK
MKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELS
KRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEE
TKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSK
SSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLG
RNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNRHDVHNIMNNSGEKEEKKI
SASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIM
FLPDDIYRNENE
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| BDBM25403 |
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| BDBM8737 |
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| Name | BDBM25403 |
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| Synonyms: | 4‐(2,4‐dichlorophenoxy)‐3‐hydroxybenzonitrile (19) | 4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile | Triclosan derivative, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H7Cl2NO2 |
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| Mol. Mass. | 280.106 |
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| SMILES | Oc1cc(ccc1Oc1ccc(Cl)cc1Cl)C#N |
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| Structure | 
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