| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Enoyl-ACP reductase |
|---|
| Ligand | BDBM25408 |
|---|
| Substrate/Competitor | BDBM8737 |
|---|
| Meas. Tech. | PfENR Enzymatic Inhibition Assay |
|---|
| pH | 7.9±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 210±60 nM |
|---|
| Citation |  Freundlich, JS; Wang, F; Tsai, HC; Kuo, M; Shieh, HM; Anderson, JW; Nkrumah, LJ; Valderramos, JC; Yu, M; Kumar, TR; Valderramos, SG; Jacobs, WR; Schiehser, GA; Jacobus, DP; Fidock, DA; Sacchettini, JC X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy. J Biol Chem282:25436-44 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Enoyl-ACP reductase |
|---|
| Name: | Enoyl-ACP reductase |
|---|
| Synonyms: | Enoyl-ACP Reductase (PfENR) | Enoyl-ACP reductase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49844.02 |
|---|
| Organism: | Plasmodium falciparum |
|---|
| Description: | Q9BJJ9 |
|---|
| Residue: | 432 |
|---|
| Sequence: | MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNK
MKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELS
KRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEE
TKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSK
SSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLG
RNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNRHDVHNIMNNSGEKEEKKI
SASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIM
FLPDDIYRNENE
|
|
|
|---|
| BDBM25408 |
|---|
| BDBM8737 |
|---|
| Name | BDBM25408 |
|---|
| Synonyms: | 2-(2,4-dichlorophenoxy)-5-propylphenol | Triclosan derivative, 9 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H14Cl2O2 |
|---|
| Mol. Mass. | 297.176 |
|---|
| SMILES | CCCc1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
