| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM25826 |
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| Substrate/Competitor | BDBM18044 |
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| Meas. Tech. | DHFR Inhibition Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1360±26 nM |
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| Citation |  Bolstad, DB; Bolstad, ES; Frey, KM; Wright, DL; Anderson, AC Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium. J Med Chem51:6839-52 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM25826 |
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| BDBM18044 |
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| Name | BDBM25826 |
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| Synonyms: | 5-[(3R)-3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | propargyl-based inhibitor, R-10a |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N4O |
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| Mol. Mass. | 358.4363 |
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| SMILES | COc1cc(cc(c1)-c1ccccc1)[C@@H](C)C#Cc1c(C)nc(N)nc1N |r| |
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| Structure | 
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