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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM50242731 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| IC50 | 16.0±n/a nM | ||
| Citation |  Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent US9932350 Publication Date 4/3/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
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| BDBM50242731 | |||
| n/a | |||
| Name | BDBM50242731 | ||
| Synonyms: | CHEMBL4089544 | US9932350, 2-14 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H24N4O | ||
| Mol. Mass. | 300.3987 | ||
| SMILES | COc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1 |r,wU:11.10,wD:14.17,(19.39,-7.66,;19.39,-9.2,;20.73,-9.97,;20.72,-11.51,;22.06,-12.28,;23.39,-11.5,;24.72,-12.27,;26.06,-11.5,;26.05,-9.95,;24.71,-9.19,;24.71,-7.65,;26.03,-6.87,;26.02,-5.34,;27.36,-4.57,;28.7,-5.33,;28.7,-6.87,;27.37,-7.64,;30.03,-4.56,;31.36,-5.33,;30.03,-3.02,;23.39,-9.96,;22.05,-9.2,)| | ||
| Structure | 
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