Reaction Details |
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Target | Lysine-specific demethylase 4E |
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Ligand | BDBM26121 |
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Substrate/Competitor | Histone H3 fragment substrate |
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Meas. Tech. | FDH Coupled Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 710000±n/a nM |
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Comments | IC50=320 uM with 30 min preincubation. |
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Citation | Rose, NR; Ng, SS; Mecinovic;, J; Liénard, MR; Bello, SH; Sun, Z; McDonough, MA; Oppermann, U; Schofield, CJ Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases. J Med Chem51:7053-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Lysine-specific demethylase 4E |
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Name: | Lysine-specific demethylase 4E |
Synonyms: | 2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E) |
Type: | Enzyme |
Mol. Mass.: | 56815.71 |
Organism: | Homo sapiens (Human) |
Description: | B2RXH2 |
Residue: | 506 |
Sequence: | MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
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BDBM26121 |
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Histone H3 fragment substrate |
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Name: | Histone H3 fragment substrate |
Synonyms: | H3K9me3 |
Type: | 8-mer |
Mol. Mass.: | 1066.23 |
Organism: | n/a |
Description: | 2-OG as co-substrate. |
Residue: | 10 |
Sequence: | |