| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-1 [T204D] |
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| Ligand | BDBM282852 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| IC50 | 0.800±n/a nM |
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| Citation |  Kinsella, T; Gelman, M; Hong, H; Darwish, IS; Singh, R; Yu, J; Borzilleri, RM; Velaparthi, U; Liu, P; Darne, CP; Rahaman, H; Warrier, JS TGF-β inhibitors US Patent US10287295 Publication Date 5/14/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| TGF-beta receptor type-1 [T204D] |
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| Name: | TGF-beta receptor type-1 [T204D] |
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| Synonyms: | ALK5 | SKR4 | TGF-beta receptor type-1 (T204D) | TGF-betaR1 T204D | TGFBR1 | TGFBR1T204D | TGFR-1 (T204D) | TGFR1_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 55981.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36897[T204D] |
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| Residue: | 503 |
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| Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
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|
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| BDBM282852 |
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| n/a |
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| Name | BDBM282852 |
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| Synonyms: | 6-(4-(3-chloro-4-fluorophenyl)-1-cyclobutyl-1H- imidazol-5-yl)imidazo[1,2-b]pyridazine-3-carbonitrile | US10287295, Example 58' | US11352360, Example 58' | US9884868, Example 58' |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14ClFN6 |
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| Mol. Mass. | 392.817 |
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| SMILES | Fc1ccc(cc1Cl)-c1ncn(C2CCC2)c1-c1ccc2ncc(C#N)n2n1 |
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| Structure | 
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