| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase B |
|---|
| Ligand | BDBM387187 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| IC50 | 1.000±n/a nM |
|---|
| Citation |  Xi, N; Li, M; Li, X; Chen, W; Zhang, T; Hu, H; Dai, W; Wu, Y Substituted heteroaryl compounds and methods of use US Patent US9938257 Publication Date 4/10/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase B |
|---|
| Name: | Aurora kinase B |
|---|
| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39327.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96GD4 |
|---|
| Residue: | 344 |
|---|
| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
|---|
| BDBM387187 |
|---|
| n/a |
|---|
| Name | BDBM387187 |
|---|
| Synonyms: | 1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol | US9938257, Example 39 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H28ClN7O3S |
|---|
| Mol. Mass. | 469.989 |
|---|
| SMILES | CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
