| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TGF-beta receptor type-2 |
|---|
| Ligand | BDBM387327 |
|---|
| Substrate/Competitor | n/a |
|---|
| IC50 | 8060±n/a nM |
|---|
| Citation |  Borzilleri, RM; Fink, BE; Harikrishnan, LS; Sankara Warrier, J TGF beta receptor antagonists US Patent US10292985 Publication Date 5/21/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TGF-beta receptor type-2 |
|---|
| Name: | TGF-beta receptor type-2 |
|---|
| Synonyms: | TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 64559.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586859 |
|---|
| Residue: | 567 |
|---|
| Sequence: | MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
LEHLDRLSGRSCSEEKIPEDGSLNTTK
|
|
|
|---|
| BDBM387327 |
|---|
| n/a |
|---|
| Name | BDBM387327 |
|---|
| Synonyms: | 6-methoxy-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]quinolin-4-amine | US10292985, Example 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H18N6O |
|---|
| Mol. Mass. | 382.4179 |
|---|
| SMILES | COc1ccc2nccc(Nc3nc(nn4cccc34)-c3cccc(C)n3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
