| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-2 |
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| Ligand | BDBM387334 |
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| Substrate/Competitor | n/a |
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| IC50 | 7640±n/a nM |
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| Citation |  Borzilleri, RM; Fink, BE; Harikrishnan, LS; Sankara Warrier, J TGF beta receptor antagonists US Patent US10292985 Publication Date 5/21/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-2 |
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| Name: | TGF-beta receptor type-2 |
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| Synonyms: | TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64559.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586859 |
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| Residue: | 567 |
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| Sequence: | MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
LEHLDRLSGRSCSEEKIPEDGSLNTTK
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| BDBM387334 |
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| n/a |
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| Name | BDBM387334 |
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| Synonyms: | N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1,6-naphthyridin-4-amine | US10292985, Example 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15N7 |
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| Mol. Mass. | 353.38 |
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| SMILES | Cc1cccc(n1)-c1nc(Nc2ccnc3ccncc23)c2cccn2n1 |
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| Structure | 
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