Ki Summary

Reaction Details

Report a problem with these data

Target

Interleukin-1 receptor-associated kinase 4

Ligand

BDBM388449

Substrate/Competitor

n/a

Meas. Tech.

Kinase Assay

IC50

19.0±n/a nM

Citation

Altman, MD; Andresen, BM; Brubaker, JD; Donofrio, A; Fischmann, T; Gibeau, CR; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF; Torres, L Inhibitors of IRAK4 activity US Patent US9943516 Publication Date 4/17/2018

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 4

Name:

Interleukin-1 receptor-associated kinase 4

Synonyms:

Type:

Protein

Mol. Mass.:

51519.08

Organism:

Homo sapiens (Human)

Description:

Q9NWZ3

Residue:

460

Sequence:

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

BDBM388449

n/a

Name

BDBM388449

Synonyms:

6-cyclohexyl-N- (trans-4- morpholin-4- ylcyclohexyl) quinazolin-4-amine | US9943516, 1-8

Type

Small organic molecule

Emp. Form.

C24H34N4O

Mol. Mass.

394.553

SMILES

C1CCC(CC1)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:18.22,wD:15.15,(-.38,8,;.39,6.66,;-.38,5.33,;-1.92,5.33,;-2.69,6.66,;-1.92,8,;-2.69,4,;-4.23,4,;-5,2.66,;-4.23,1.33,;-5,-0,;-4.23,-1.34,;-2.69,-1.34,;-1.92,-0,;-.38,-0,;.39,-1.34,;-.38,-2.67,;.39,-4,;1.92,-4,;2.69,-2.67,;1.92,-1.34,;2.69,-5.33,;1.92,-6.66,;2.69,-8,;4.23,-8,;5,-6.66,;4.23,-5.33,;-2.69,1.33,;-1.92,2.66,)|

Structure