Reaction Details |
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Target | Gag-Pol polyprotein [588-1027,K691N,Y769C]/[588-1147,K691N,Y769C] |
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Ligand | BDBM27607 |
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Substrate/Competitor | poly rC/biotin-dG15 |
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Meas. Tech. | Reverse Transcriptase Assay |
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IC50 | 28±n/a nM |
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Citation | Gagnon, A; Landry, S; Coulombe, R; Jakalian, A; Guse, I; Thavonekham, B; Bonneau, PR; Yoakim, C; Simoneau, B Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases. Bioorg Med Chem Lett19:1199-205 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Gag-Pol polyprotein [588-1027,K691N,Y769C]/[588-1147,K691N,Y769C] |
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Name: | Gag-Pol polyprotein [588-1027,K691N,Y769C]/[588-1147,K691N,Y769C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (103N/181C) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [588-1147,K691N,Y769C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (103N/181C) Chain A | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 64411.30 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1147,K691N,Y769C] |
Residue: | 560 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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Component 2 |
Name: | Gag-Pol polyprotein [588-1027,K691N,Y769C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (103N/181C) Chain B | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 51262.02 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1027,K691N,Y769C] |
Residue: | 440 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF
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BDBM27607 |
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poly rC/biotin-dG15 |
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Name: | poly rC/biotin-dG15 |
Synonyms: | n/a |
Type: | RNA/DNA duplex |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | The incorporation of [3H]dGTP onto a (poly)rC:(biotin)dG template:primer. |
Residue: | 3 |
Sequence: | |