| Reaction Details |
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 | Report a problem with these data |
| Target | Lethal factor |
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| Ligand | BDBM27867 |
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| Substrate/Competitor | Fluorogenic LF Substrate |
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| Meas. Tech. | Fluorescence Peptide Cleavage Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | >50000±n/a nM |
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| Comments | Determination of a more accurate IC50 value was precluded by the limited solubility of this compound. |
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| Citation |  Agrawal, A; de Oliveira, CA; Cheng, Y; Jacobsen, JA; McCammon, JA; Cohen, SM Thioamide Hydroxypyrothiones Supersede Amide Hydroxypyrothiones in Potency against Anthrax Lethal Factor. J Med Chem52:1063-74 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Lethal factor |
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| Name: | Lethal factor |
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| Synonyms: | Anthrax Lethal Factor (LF) | Anthrax lethal factor | Antrax lethal toxin | LEF_BACAN | lef | lethal factor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93758.56 |
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| Organism: | Bacillus anthracis |
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| Description: | ChEMBL_1460338 |
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| Residue: | 809 |
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| Sequence: | MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEE
RNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGD
ITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNV
YYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLE
QNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLAR
YEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSS
DFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYD
INQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLT
ATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSP
DTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNIN
QEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNG
RFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHE
FGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHST
DHAERLKVQKNAPKTFQFINDQIKFIINS
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| BDBM27867 |
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| Fluorogenic LF Substrate |
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| Name: | Fluorogenic LF Substrate |
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| Synonyms: | n/a |
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| Type: | Peptide |
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| Mol. Mass.: | 6797.59 |
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| Organism: | n/a |
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| Description: | Cou = 7-Hydroxy-4-methyl-3-acetylcoumarinyl; QSY-35 = N-((4-((7-Nitro-2,1,3-benzoxzdiazol-4-yl)amino)phenyl)acetyl. |
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| Residue: | 61 |
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| Sequence: | CNNLELYSLYSLYSLYSVALLEPRILEGLNLEASNALAALATHRASPLYSQSYGLYGLYN
H
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