| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 11 |
|---|
| Ligand | BDBM392311 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | SHP2 Allosteric Inhibition Assay |
|---|
| IC50 | 94.0±n/a nM |
|---|
| Citation |  Chen, Z; Dore, M; Fortanet, JG; Karki, R; Kato, M; LaMarche, MJ; Perez, LB; Williams, S; Sendzik, M 1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions therefor for inhibiting the activity of SHP2 US Patent US10301278 Publication Date 5/28/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 11 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 11 |
|---|
| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
|---|
| Type: | Protein phosphatase |
|---|
| Mol. Mass.: | 68443.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q06124 |
|---|
| Residue: | 593 |
|---|
| Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
|
|
|
|---|
| BDBM392311 |
|---|
| n/a |
|---|
| Name | BDBM392311 |
|---|
| Synonyms: | N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-3-chloropropanamide | US10301278, Example 16 | US10301278, Example 17 | US10301278, Example 18 | US10301278, Example 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H21ClN6S |
|---|
| Mol. Mass. | 364.896 |
|---|
| SMILES | CC1(N)CCN(CC1)c1cnc(Sc2cccc(N)c2Cl)c(N)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
