| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D-alanine--D-alanyl carrier protein ligase |
|---|
| Ligand | BDBM392742 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | in vitro DltA activity assay |
|---|
| IC50 | 180±n/a nM |
|---|
| Citation |  Atamanyuk, D; Chevreuil, F; Faivre, F; Lecointe, N; Ledoussal, B; Oliveira, C; Simon, C; Gerusz, V Heteroaromatic derivatives and their use as pharmaceuticals US Patent US10301305 Publication Date 5/28/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D-alanine--D-alanyl carrier protein ligase |
|---|
| Name: | D-alanine--D-alanyl carrier protein ligase |
|---|
| Synonyms: | D-alanine--poly(phosphoribitol) ligase subunit 1 | DAE | DCL | DLTA_STRA5 | dltA |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57170.25 |
|---|
| Organism: | Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) |
|---|
| Description: | n/a |
|---|
| Residue: | 511 |
|---|
| Sequence: | MIHDMIKTIEHFAETQADFPVYDILGEVHTYGQLKVDSDSLAAHIDSLGLVEKSPVLVFG
GQEYEMLATFVALTKSGHAYIPVDQHSALDRIQAIMTVAQPSLIISIGEFPLEVDNVPIL
DVSQVSAIFEEKTPYEVTHSVKGDDNYYIIFTSGTTGLPKGVQISHDNLLSFTNWMISDD
EFSVPERPQMLAQPPYSFDLSVMYWAPTLAMGGTLFALPKTVVNDFKKLFATINELPIQV
WTSTPSFADMALLSNDFNSETLPQLTHFYFDGEELTVKTAQKLRQRFPKARIVNAYGPTE
ATVALSAVAITDEMLETCKRLPIGYTKDDSPTYVIDEEGHKLPNGEQGEIIIAGPAVSKG
YLNNPEKTAEAFFQFEGLPAYHTGDLGSMTDEGLLLYGGRMDFQIKFNGYRIELEDVSQN
LNKSQYVKSAVAVPRYNKDHKVQNLLAYIVLKEGVRDDFERDLDLTKAIKEDLKDIMMDY
MMPSKFIYREDLPLTPNGKIDIKGLMSEVNK
|
|
|
|---|
| BDBM392742 |
|---|
| n/a |
|---|
| Name | BDBM392742 |
|---|
| Synonyms: | US10301305, Example 6 | {1-[7-(1-Cyclohexyl-1H-benzimidazol-5-yl)-3H-imidazo[4,5-b]pyridin-5-yl]-4-hydroxymethyl-piperidin-4-yl}-methanol |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H32N6O2 |
|---|
| Mol. Mass. | 460.5713 |
|---|
| SMILES | OCC1(CO)CCN(CC1)c1cc(-c2ccc3n(cnc3c2)C2CCCCC2)c2nc[nH]c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
