| Reaction Details |
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 | Report a problem with these data |
| Target | D-alanine--D-alanyl carrier protein ligase |
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| Ligand | BDBM392781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | in vitro DltA activity assay |
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| IC50 | 40.0±n/a nM |
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| Citation |  Atamanyuk, D; Chevreuil, F; Faivre, F; Lecointe, N; Ledoussal, B; Oliveira, C; Simon, C; Gerusz, V Heteroaromatic derivatives and their use as pharmaceuticals US Patent US10301305 Publication Date 5/28/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| D-alanine--D-alanyl carrier protein ligase |
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| Name: | D-alanine--D-alanyl carrier protein ligase |
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| Synonyms: | D-alanine--poly(phosphoribitol) ligase subunit 1 | DAE | DCL | dltA |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56736.38 |
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| Organism: | Enterococcus faecium E1679 |
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| Description: | Q3XZT7 |
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| Residue: | 504 |
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| Sequence: | MEIKTIIEAIDDWGINEPDRVAYQADETHTFGELKQASDALAYYLEKKVEGDGPIVVFGN
LEFEMIVSFLGVVKSGHAYLPIEEHTPKERILSIFRVAKPSMVISIGDWIEDIPSVPVIT
KKEFQEIKKIPVGFYPRNSVKGTENFYIIFTSGTTGEPKGVQISHDNLVSFVQWTMEDFG
IKPGMHFLAQAPFSFDLSVFSIYPALVSGGMLKPLNKAVVQDFRQLFATLPALKLNVWVS
TPSFMDICLMEPTFNGENVPELDMFLFCGEELTKKTAESLLDRFPNARIYNTYGPTEATV
AISSIQIDQHVLDSYDRLPIGYVKKDTKVSIVQEGKPVSKGETGEIIIAGPSVSKGYLNN
PEKTAAAFFCQNDLASYHTGDAGRLDEYGLLFYEGRMDQQVKLHGYRIELGDIEHYLLQD
NRIKQAVVVPKYQGTKVQQLVAFVVLENKTKQPDFQLTKSIKEQLLEVVMDYMIPQKFHY
VDLLPQTVNGKIDRKKLTAEVNPE
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| BDBM392781 |
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| n/a |
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| Name | BDBM392781 |
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| Synonyms: | 1′-((1R,2R)-2-Fluoro-cyclohexyl)-6-[(2-hydroxy-ethyl)-methyl-amino]-1H,1′H-[4,5′]]bibenzimidazolyl-7-carboxamide | US10301305, Example 171 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27FN6O2 |
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| Mol. Mass. | 450.5086 |
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| SMILES | CN(CCO)c1cc(-c2ccc3n(cnc3c2)[C@@H]2CCCC[C@H]2F)c2nc[nH]c2c1C(N)=O |r| |
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| Structure | 
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