| Reaction Details |
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 | Report a problem with these data |
| Target | D-alanine--D-alanyl carrier protein ligase |
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| Ligand | BDBM392796 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | in vitro DltA activity assay |
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| IC50 | 1.40±n/a nM |
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| Citation |  Atamanyuk, D; Chevreuil, F; Faivre, F; Lecointe, N; Ledoussal, B; Oliveira, C; Simon, C; Gerusz, V Heteroaromatic derivatives and their use as pharmaceuticals US Patent US10301305 Publication Date 5/28/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| D-alanine--D-alanyl carrier protein ligase |
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| Name: | D-alanine--D-alanyl carrier protein ligase |
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| Synonyms: | D-alanine--poly(phosphoribitol) ligase subunit 1 | DAE | DCL | dltA |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56357.51 |
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| Organism: | Enterococcus faecalis (strain ATCC 700802 / V583) |
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| Description: | n/a |
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| Residue: | 506 |
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| Sequence: | MEKVINMIQTIDEWARKEPQRPVYLTEEKVSTYGELKEKSDNLAAYLAELKTDKSAIVVY
GELDFEMIVSFLGASKAGFSYIPIDAHTPKERIELILNVAKPTAVIAVHEWPELATEVPV
ITAEELTEMMMHAPRHAPALMPVTGASNYYIIFTSGTTGVPKGVQISHDNLVSFTNWLLQ
DFGLEEGARFLAQAPYSFDLSVMSIYPALALGGSLTPLPNEIINDFKQLFTRLPQLTIDV
WVSTPSFIELCLMEPSFDGEHLPALRTFLFCGEELPKPTAEKLAARFPTAHIYNTYGPTE
ATVAISAIEITQEVLKSVQRLPIGYVKEDTQIYIMEGMSKLPAGEIGEIVIAGPSVSKGY
LNNPAKTAEAFFQLDGVPAYRTGDAGKLVDNLLQYEGRLDFQIKLHGYRIELEEVDHHLT
NVSYVKQAVVVPKYQGNKVQQLIAYVVPQAHEFSSDFQLTKAIKQELATLTMDYMIPQKF
VYVEQLPLTSNGKIDRKGLMNEVNAT
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| BDBM392796 |
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| n/a |
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| Name | BDBM392796 |
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| Synonyms: | 5-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-7-(1-tetrahydropyran-3-ylbenzimidazol-5-yl)-3H-benzimidazole-4-carboxamide methanesulfonic acid salt | US10301305, Example 215 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N6O3 |
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| Mol. Mass. | 474.5548 |
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| SMILES | CN1CCC[C@@H]1COc1cc(-c2ccc3n(cnc3c2)C2CCCOC2)c2nc[nH]c2c1C(N)=O |r| |
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| Structure | 
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