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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-interacting serine/threonine-protein kinase 3 | ||
| Ligand | BDBM392939 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | RIPK3 HTRF Kinase Assay | ||
| IC50 | <30±n/a nM | ||
| Citation |  Hart, AC; Pitts, WJ; Mastalerz, H; Guo, J; Brown, GD Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors US Patent US10301306 Publication Date 5/28/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Receptor-interacting serine/threonine-protein kinase 3 | |||
| Name: | Receptor-interacting serine/threonine-protein kinase 3 | ||
| Synonyms: | RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56886.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_881455 | ||
| Residue: | 518 | ||
| Sequence: |
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| BDBM392939 | |||
| n/a | |||
| Name | BDBM392939 | ||
| Synonyms: | US10301306, Example 137 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H19FN4O2 | ||
| Mol. Mass. | 438.4531 | ||
| SMILES | Oc1ccccc1-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 |(-2.63,1.99,;-1.54,3.08,;-1.94,4.57,;-.85,5.66,;.63,5.26,;1.03,3.77,;-.06,2.68,;.34,1.19,;1.81,.72,;1.81,-.82,;3.14,-1.59,;4.47,-.82,;4.47,.72,;3.14,1.49,;3.14,3.03,;.34,-1.3,;-.06,-2.79,;1.03,-3.88,;2.52,-3.48,;3.61,-4.57,;3.21,-6.05,;4.3,-7.14,;1.72,-6.45,;.58,-5.38,;-.91,-5.78,;-2.41,-6.1,;-.56,-.05,;-2.1,-.05,;-2.87,1.28,;-4.41,1.28,;-5.18,-.05,;-4.41,-1.39,;-2.87,-1.39,)| | ||
| Structure | 
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