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TargetPeroxisome proliferator-activated receptor alpha
LigandBDBM28771
Substrate/CompetitorBDBM10852
Meas. Tech.Cell-Based Transcription Assay
EC50>10000±n/a nM
Citation Epple, RAzimioara, MRusso, RXie, YWang, XCow, CWityak, JKaranewsky, DBursulaya, BKreusch, ATuntland, TGerken, AIskandar, MSaez, EMartin Seidel, HTian, SS 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2. Bioorg Med Chem Lett16:5488-92 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Peroxisome proliferator-activated receptor alpha
Name:Peroxisome proliferator-activated receptor alpha
Synonyms:NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:Enzyme
Mol. Mass.:52222.08
Organism:Homo sapiens (Human)
Description:Q07869
Residue:468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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  Blast E-value cutoff:
BDBM28771
BDBM10852
NameBDBM28771
Synonyms:2-[3-(4-{[2-(2,4-dichlorophenoxy)ethyl]carbamoyl}-5-phenyl-1,2-oxazol-3-yl)-4-methoxyphenyl]acetic acid | trisubstituted isoxazole, 17f
TypeSmall organic molecule
Emp. Form.C27H22Cl2N2O6
Mol. Mass.541.379
SMILESCOc1ccc(CC(O)=O)cc1-c1noc(c1C(=O)NCCOc1ccc(Cl)cc1Cl)-c1ccccc1
Structure
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