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TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
LigandBDBM24400
Substrate/CompetitorBDBM14700
Meas. Tech.DHODH Inhibition Assay
IC50>200000±n/a nM
Citation Gujjar, R; Marwaha, A; El Mazouni, F; White, J; White, KL; Creason, S; Shackleford, DM; Baldwin, J; Charman, WN; Buckner, FS; Charman, S; Rathod, PK; Phillips, MA Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem52:1864-72 (2009) [PubMed]  Article
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Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
Synonyms:DHODH | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | PYRD_HUMAN
Type:Enzyme
Mol. Mass.:39678.95
Organism:Homo sapiens (Human)
Description:Recombinant human DHODH (amino acids 30 to 395) was cloned and expressed in E. coli.
Residue:366
Sequence:
ATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRN
PVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFN
SHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLV
VNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIAS
VVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPI
IGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAI
GADHRR
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BDBM24400
BDBM14700
NameBDBM24400
Synonyms:5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | JMC521864 Compund DSM1 | Triazolopyrimidine-Based Compound, 7
TypeSmall organic molecule
Emp. Form.C16H13N5
Mol. Mass.275.3079
SMILESCc1cc(Nc2ccc3ccccc3c2)n2ncnc2n1
Structure
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