Reaction Details | |||
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Target | Alpha-1B adrenergic receptor | ||
Ligand | BDBM29561 | ||
Substrate/Competitor | BDBM29568 | ||
Meas. Tech. | Radioligand Binding Assay (Ki) | ||
Ki | 85±n/a nM | ||
Citation | Paluchowska, MH; Bugno, R; Duszyńska, B; Tatarczyńska, E; Nikiforuk, A; Lenda, T; Chojnacka-Wójcik, E The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines. Bioorg Med Chem15:7116-25 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Alpha-1B adrenergic receptor | |||
Name: | Alpha-1B adrenergic receptor | ||
Synonyms: | ADA1B_RAT | Adra1b | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha adrenergic receptor 1A and 1B | Alpha-1 Adrenergic Receptor | Alpha-1Adrenoceptor | Alpha-1B adrenergic receptor | Alpha-1B adrenoreceptor | adrenergic Alpha1B | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 56606.71 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Receptor binding assays were performed using rat cortical membranes. | ||
Residue: | 515 | ||
Sequence: |
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BDBM29561 | |||
BDBM29568 | |||
Name | BDBM29561 | ||
Synonyms: | 1-(m-trifluorophenyl)piperazine, 8 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H28F3N3O2 | ||
Mol. Mass. | 423.4718 | ||
SMILES | FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)CCCC1=O |(9.97,11.47,;11.29,10.68,;12.06,12.02,;12.62,9.9,;10.5,9.37,;11.24,8.02,;10.45,6.7,;8.91,6.73,;8.16,8.08,;8.96,9.39,;6.62,8.08,;5.82,9.39,;4.28,9.34,;3.54,7.99,;4.35,6.68,;5.89,6.72,;2,7.99,;1.23,9.32,;-.31,9.32,;-1.08,7.99,;-.31,6.65,;1.23,6.65,;-2.62,7.99,;-3.43,9.3,;-2.66,10.63,;-4.97,9.24,;-5.69,7.88,;-4.88,6.58,;-3.34,6.63,;-2.57,5.3,)| | ||
Structure |